• Publications
  • Influence
A brief history of opiates, opioid peptides, and opioid receptors.
  • M. Brownstein
  • History
    Proceedings of the National Academy of Sciences…
  • 15 June 1993
Most authors* agree that, as early as the eighth century A.D., Arab traders brought opium to India and China and that between the tenth and thirteenth centuries opium made its way from Asia Minor to all parts of Europe.
A role for ASIC3 in the modulation of high-intensity pain stimuli
It is postulated that ASIC3 is involved in modulating moderate- to high-intensity pain sensation, when stimuli of moderate to high intensity were used.
Identification of insulin in rat brain.
Brain insulin was indistinguishable from authentic pancreatic insulin, based on its behavior in radioimmunoassay, radioreceptor assay, and bioassay and its chromatographic pattern on Sephadex G-50 column chromatography.
Concentrations of insulin and insulin receptors in the brain are independent of peripheral insulin levels. Studies of obese and streptozotocin-treated rodents.
Brain insulin and brain receptor content, which is equivalent to receptor content on peripheral tissues, appears to be regulated entirely independently of hormone and receptor in the periphery, consistent with the hypothesis that insulin in the central nervous system is synthesized by the neural elements, and plays a role in thecentral nervous system which is unrelated to peripheral glucose metabolism.
Neurologic and psychiatric manifestations in a family with a mutation in exon 2 of the guanosine triphosphate-cyclohydrolase gene.
Study of additional families with hereditary progressive and/or levodopa-responsive dystonia using modern molecular methods will be necessary to confirm the neuropsychiatric spectrum of this disorder, in which important clinical features may be unrecognized and thus inappropriately managed.
Thyrotropin-Releasing Hormone in Specific Nuclei of Rat Brain
The regional distribution of thyrotropin-releasing hormone (TRH) in rat brain was studied. The greatest concentration of TRH was found in the median eminence. High concentrations were also found in
Molecular Cloning and Functional Characterization of a Vasotocin Receptor Subtype That Is Expressed in the Shell Gland and Brain of the Domestic Chicken1
The cloned VT1 receptor may mediate contractions of the shell gland during oviposition and activate reproductive behaviors known to be stimulated by vasotocin in lower vertebrates.
The regional distribution of somatostatin in the rat brain.
The concentration of SRIF was highest in the median eminence and arcuate nucleus although all of the hypothalmic nuclei contained some fo this material, and the implications of this distribution are discussed.