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Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland
TLDR
Rhythmic adrenergic signals originated by the clock direct ICER expression by stimulation of the cAMP signal transduction pathway are derived. Expand
Kisspeptin Mediates the Photoperiodic Control of Reproduction in Hamsters
TLDR
It is proposed that photoperiod, via melatonin, modulates KiSS-1 signaling to drive the reproductive axis, consistent with a role of Ki SS1/GPR54 in the seasonal control of reproduction. Expand
Feeding Cues Alter Clock Gene Oscillations and Photic Responses in the Suprachiasmatic Nuclei of Mice Exposed to a Light/Dark Cycle
TLDR
It is shown that diurnal hypocaloric feeding affects not only the temporal organization of the SCN clockwork and circadian outputs in mice under light/dark cycle but also photic responses of the circadian system, thus indicating that energy metabolism modulates circadian rhythmicity and gating of photic inputs in mammals. Expand
Synchronization of the Molecular Clockwork by Light- and Food-Related Cues in Mammals
TLDR
Time of feeding, as modulated by temporal restricted feeding, is a potent 'Zeitgeber' (synchronizer) for peripheral oscillators with only weak synchronizing influence on the SCN clockwork when restricted feeding is coupled with caloric restriction, indicating that theSCN function is sensitive to metabolic cues. Expand
RFamide-related peptide gene is a melatonin-driven photoperiodic gene.
TLDR
Evidence is presented that the gene orthologous to GnIH, the RFamide-related peptide (RFRP) gene, expressed in the mediobasal hypothalamus, is strongly regulated by the length of the photoperiod, via melatonin, which raises questions on the role of RFRP as a general inhibitor of reproduction and evoke new perspectives for understanding how melatonin controls seasonal processes via hypothalamic targets. Expand
Daily and circadian expression of neuropeptides in the suprachiasmatic nuclei of nocturnal and diurnal rodents.
TLDR
The data show that AVP mRNA exhibits a clear circadian rhythm in the SCN peaking by the end of the subjective day in both species, and oscillations of VIP and GRP mRNA in theSCN are found to be clock-controlled in mice and A. ansorgei, but with different phases for peak expression. Expand
High‐fat feeding alters the clock synchronization to light
TLDR
It is demonstrated that high‐fat feeding modifies circadian synchronization to light using wheel‐running activity and body temperature rhythms as daily phase markers and photic induction of c‐FOS and P‐ERK in the suprachiasmatic nuclei was markedly reduced. Expand
Pituitary hormone FSH directs the CREM functional switch during spermatogenesis
TLDR
It is established that follicle-stimulating hormone (FSH) is responsible for the CREM switch and FSH appears to regulate CREM expression by alternative polyadenylation, which results in a dramatic enhancement of transcript stability. Expand
Melatonin regulates type 2 deiodinase gene expression in the Syrian hamster.
TLDR
Results demonstrate that in the Syrian hamster Dio2 is photoperiodically modulated via a melatonin-dependent process, and raise new perspectives for understanding how thyroid hormones are involved in the control ofPhotoperiodic neuroendocrine processes. Expand
Kisspeptin and the seasonal control of reproduction in hamsters
TLDR
It is observed that Kiss1 mRNA level in the arcuate nucleus of the Syrian hamster is lower in short photoperiod, when animals are sexually quiescent, and intracerebroventricular infusion of Kiss1 gene product, kisspeptin, in hamsters kept in shortPhotoperiod is able to override the inhibitoryphotoperiod and to reactivate sexual activity. Expand
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