The gamma-hydroxybutyrate signalling system in brain: organization and functional implications.
- M. Maitre
- BiologyProgress in neurobiology
- 1997
It is presumed that, under pathological conditions (hepatic failure, alcoholic intoxication, succinic semialdehyde dehydrogenase defects), the rate of GHB synthesis or degradation in the peripheral organ is modified and induces increased GHB levels which could interfere with the normal brain mechanisms.
THE γ-HYDROXYBUTYRATE SIGNALLING SYSTEM IN BRAIN: ORGANIZATION AND FUNCTIONAL IMPLICATIONS
- M. Maitre
- BiologyProgress in neurobiology
- 1 February 1997
Blockade of the discriminative stimulus effects of γ-hydroxybutyric acid (GHB) by the GHB receptor antagonist NCS-382
- G. Colombo, R. Agabio, G. Gessa
- Biology, PsychologyPhysiology and Behavior
- 1 September 1995
High affinity binding site for γ-hydroxybutyric acid in rat brain
- J. Benavides, J. Rumigny, M. Maitre
- Biology
- 15 March 1982
A specific gamma-hydroxybutyrate receptor ligand possesses both antagonistic and anticonvulsant properties.
- M. Maitre, V. Hechler, J. Bourguignon
- Biology, PsychologyJournal of Pharmacology and Experimental…
- 1 November 1990
The results suggest that NCS-382 may represent a harbinger for a new class of anticonvulsant drugs that most probably act by modifying the endogenous GHB system.
gamma-Hydroxybutyrate conversion into GABA induces displacement of GABAB binding that is blocked by valproate and ethosuximide.
- V. Hechler, C. Ratomponirina, M. Maitre
- BiologyJournal of Pharmacology and Experimental…
- 1 May 1997
It is demonstrated that the inhibition of GHB's conversion into GABA by rat brain membranes blocks the ability ofGHB to interfere with GABAB binding, which could explain the misinterpretation of in vitro or in vivo experiments where GHB possesses a GABA-like effect.
Immunohistochemical evidence for the presence of γ-aminobutyric acid and serotonin in one nerve cell. A study on the raphe nuclei of the rat using antibodies to glutamate decarboxylase and serotonin
- M. Belin, D. Nanopoulos, J. Pujol
- BiologyBrain Research
- 26 September 1983
γ-Aminobutyric acid and 5-hydroxytryptamine interrelationship in the rat nucleus raphe dorsalis: Combination of radioautographic and immunocytochemical techniques at light and electron microscopy…
- M. Harandi, M. Aguera, M. Belin
- BiologyNeuroscience
- 1 April 1987
gamma-Hydroxybutyrate modulates synthesis and extracellular concentration of gamma-aminobutyric acid in discrete rat brain regions in vivo.
- S. Gobaille, V. Hechler, C. Andriamampandry, V. Kemmel, M. Maitre
- BiologyJournal of Pharmacology and Experimental…
- 1999
It is demonstrated that in the rat frontal cortex in vivo, gamma-hydroxybutyrate or its agonist NCS-356 administered systemically at a high dose (500 mg/kg) increases GABA contents in dialysates via a mechanism blocked by the peripheral administration of the gamma-Hydroxy butyrate antagonist N CS-382.
A High‐Affinity, Na+‐Dependent Uptake System for γ‐Hydroxybutyrate in Membrane Vesicles Prepared from Rat Brain
- J. Benavides, J. Rumigny, J. Bourguignon, C. Wermuth, P. Mandel, M. Maitre
- Biology, ChemistryJournal of Neurochemistry
- 1 June 1982
A series of related compounds, including aryl‐or alkyl‐derivatives, has been examined for ability to inhibit GHB uptake, indicative of its possible physiological role and also of the existence of a high‐affinity uptake system for GHB.
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