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sparfloxacin

Known as: sparfloxacin [Chemical/Ingredient], 5-amino-1-cyclopropyl-7-[(3R,5S)3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-quinoline-3-carboxylic acid, cis-5-Amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
A fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription. Sparfloxacin was withdrawn… Expand
National Institutes of Health

Related topics

Related topics

39 relations

Narrower (3)

AT 4140CI 978PD 131501
AlbuterolAmiodaroneAmiodarone hydrochlorideAstemizole
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Broader (3)

Antitubercular AgentsFluoroquinolonesTopoisomerase II Inhibitors

Papers overview

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Highly Cited
2010
Highly Cited
2010
Sparfloxacin-loaded PLGA nanoparticles for sustained ocular drug delivery.
UNLABELLED Poor ocular bioavailability of drugs (<1%) from conventional eye drops (ie, solution, suspension, and ointments) is… Expand
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Highly Cited
2010
Highly Cited
2010
Metal complexes of the third-generation quinolone antimicrobial drug sparfloxacin: Structure and biological evaluation.
Five metal complexes of the third-generation quinolone antimicrobial agent sparfloxacin with Fe(3+), VO(2+), Mn(2+), Ni(2+) and… Expand
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Highly Cited
2009
Highly Cited
2009
Nickel-quinolones interaction. Part 1 - Nickel(II) complexes with the antibacterial drug sparfloxacin: structure and biological properties.
The mononuclear nickel(II) complexes with the third-generation quinolone antibacterial agent sparfloxacin in the absence or… Expand
Highly Cited
2006
Highly Cited
2006
Moxifloxacin, Ofloxacin, Sparfloxacin, and Ciprofloxacin against Mycobacterium tuberculosis: Evaluation of In Vitro and Pharmacodynamic Indices That Best Predict In Vivo Efficacy
ABSTRACT Members of the fluoroquinolone class are being actively evaluated for inclusion in tuberculosis chemotherapy regimens… Expand
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Review
2003
Review
2003
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug…
OBJECTIVE To attempt to determine the relative value of preclinical cardiac electrophysiology data (in vitro and in vivo) for… Expand
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Review
2003
Review
2003
Development of the quinolones.
Since their discovery in the early 1960s, the quinolone group of antibacterials has generated considerable clinical and… Expand
Highly Cited
1998
Highly Cited
1998
The effect of reserpine, an inhibitor of multidrug efflux pumps, on the in-vitro activities of ciprofloxacin, sparfloxacin and moxifloxacin against clinical isolates of Staphylococcus aureus.
In Staphylococcus aureus, in addition to mutations in the grl and gyr gene loci, multidrug efflux pumps like NorA contribute to… Expand
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Highly Cited
1997
Highly Cited
1997
Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones.
  • X. Pan, L. Fisher
  • Antimicrobial agents and chemotherapy
  • 1997
    • Corpus ID: 38155801
gyrA and parC mutations have been identified inn Streptococcus pneumoniae mutants stepwise selected for resistance to… Expand
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Highly Cited
1997
Highly Cited
1997
In vitro activity of Bay 12-8039, a new 8-methoxyquinolone.
  • R. Fass
  • Antimicrobial agents and chemotherapy
  • 1997
    • Corpus ID: 46631055
MICs of Bay 12-8039 and comparative antimicrobials were determined for 820 recent clinical isolates. Ciprofloxacin was… Expand
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Highly Cited
1990
Highly Cited
1990
Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones.
The norA gene cloned from chromosomal DNA of quinolone-resistant Staphylococcus aureus TK2566 conferred relatively high… Expand
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