sparfloxacin

Known as: sparfloxacin [Chemical/Ingredient], 5-amino-1-cyclopropyl-7-[(3R,5S)3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-quinoline-3-carboxylic acid, cis-5-Amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
A fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription. Sparfloxacin was withdrawn… (More)
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Copyright: © 2015 Trivedi MK, et al. This is an open-access article distributed under the terms of the Creative Commons… (More)
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Highly Cited
2010
Highly Cited
2010
UNLABELLED Poor ocular bioavailability of drugs (<1%) from conventional eye drops (ie, solution, suspension, and ointments) is… (More)
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Highly Cited
2007
Highly Cited
2007
Members of the fluoroquinolone class are being actively evaluated for inclusion in tuberculosis chemotherapy regimens, and we… (More)
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Review
2003
Review
2003
OBJECTIVE To attempt to determine the relative value of preclinical cardiac electrophysiology data (in vitro and in vivo) for… (More)
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Highly Cited
2003
Highly Cited
2003
Quinolone resistance encoded by the qnr gene and mediated by plasmid pMG252 was discovered in a clinical strain of Klebsiella… (More)
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Highly Cited
1999
Highly Cited
1999
While meropenem MICs were strongly influenced by the presence or absence of the MexAB-OprM efflux pump in both OprD-proficient… (More)
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1998
1998
In Staphylococcus aureus, in addition to mutations in the grl and gyr gene loci, multidrug efflux pumps like NorA contribute to… (More)
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Highly Cited
1997
Highly Cited
1997
gyrA and parC mutations have been identified inn Streptococcus pneumoniae mutants stepwise selected for resistance to… (More)
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Review
1993
Review
1993
Sparfloxacin is a recently developed fluoroquinolone. The drug has shown potent antimicrobial activity against a wide range of… (More)
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Highly Cited
1990
Highly Cited
1990
The norA gene cloned from chromosomal DNA of quinolone-resistant Staphylococcus aureus TK2566 conferred relatively high… (More)
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