Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

sparfloxacin

Known as: sparfloxacin [Chemical/Ingredient], 5-amino-1-cyclopropyl-7-[(3R,5S)3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-quinoline-3-carboxylic acid, cis-5-Amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
A fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription. Sparfloxacin was withdrawn… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
UNLABELLED Poor ocular bioavailability of drugs (<1%) from conventional eye drops (ie, solution, suspension, and ointments) is… Expand
  • table 1
  • table 2
  • figure 2
  • figure 1
  • figure 4
Highly Cited
2010
Highly Cited
2010
Five metal complexes of the third-generation quinolone antimicrobial agent sparfloxacin with Fe(3+), VO(2+), Mn(2+), Ni(2+) and… Expand
  • table 1
  • figure 1
  • figure 2
  • table 2
  • figure 3
Highly Cited
2009
Highly Cited
2009
The mononuclear nickel(II) complexes with the third-generation quinolone antibacterial agent sparfloxacin in the absence or… Expand
Highly Cited
2006
Highly Cited
2006
ABSTRACT Members of the fluoroquinolone class are being actively evaluated for inclusion in tuberculosis chemotherapy regimens… Expand
  • table 1
  • table 2
  • table 3
  • figure 1
  • figure 2
Review
2003
Review
2003
OBJECTIVE To attempt to determine the relative value of preclinical cardiac electrophysiology data (in vitro and in vivo) for… Expand
  • figure 1
  • figure 2
  • figure 3
Review
2003
Review
2003
Since their discovery in the early 1960s, the quinolone group of antibacterials has generated considerable clinical and… Expand
Highly Cited
1998
Highly Cited
1998
In Staphylococcus aureus, in addition to mutations in the grl and gyr gene loci, multidrug efflux pumps like NorA contribute to… Expand
  • table I
  • table II
  • table III
  • table IV
Highly Cited
1997
Highly Cited
1997
  • X. Pan, L. Fisher
  • Antimicrobial agents and chemotherapy
  • 1997
  • Corpus ID: 38155801
gyrA and parC mutations have been identified inn Streptococcus pneumoniae mutants stepwise selected for resistance to… Expand
  • table 1
  • figure 2
  • figure 1
  • table 2
Highly Cited
1997
Highly Cited
1997
  • R. Fass
  • Antimicrobial agents and chemotherapy
  • 1997
  • Corpus ID: 46631055
MICs of Bay 12-8039 and comparative antimicrobials were determined for 820 recent clinical isolates. Ciprofloxacin was… Expand
  • figure 1
  • table 2
Highly Cited
1990
Highly Cited
1990
The norA gene cloned from chromosomal DNA of quinolone-resistant Staphylococcus aureus TK2566 conferred relatively high… Expand