sparfloxacin

Known as: sparfloxacin [Chemical/Ingredient], 5-amino-1-cyclopropyl-7-[(3R,5S)3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-quinoline-3-carboxylic acid, cis-5-Amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
A fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription. Sparfloxacin was withdrawn… (More)
National Institutes of Health

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Narrower (3)

AT 4140CI 978PD 131501
AlbuterolAmiodaroneAmiodarone hydrochlorideAstemizole
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Broader (3)

Antitubercular AgentsFluoroquinolonesTopoisomerase II Inhibitors

Papers overview

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Highly Cited
2015
Highly Cited
2015
Fourier Transform Infrared and Ultraviolet-Visible Spectroscopic Characterization of Biofield Treated Salicylic Acid and Sparfloxacin
Copyright: © 2015 Trivedi MK, et al. This is an open-access article distributed under the terms of the Creative Commons… (More)
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Highly Cited
2010
Highly Cited
2010
Sparfloxacin-loaded PLGA nanoparticles for sustained ocular drug delivery.
UNLABELLED Poor ocular bioavailability of drugs (<1%) from conventional eye drops (ie, solution, suspension, and ointments) is… (More)
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Highly Cited
2007
Highly Cited
2007
Moxifloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against Mycobacterium tuberculosis: evaluation of in vitro and pharmacodynamic indices that best predict in vivo efficacy.
Members of the fluoroquinolone class are being actively evaluated for inclusion in tuberculosis chemotherapy regimens, and we… (More)
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Review
2003
Review
2003
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug…
OBJECTIVE To attempt to determine the relative value of preclinical cardiac electrophysiology data (in vitro and in vivo) for… (More)
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Highly Cited
2003
Highly Cited
2003
Prevalence of plasmid-mediated quinolone resistance.
Quinolone resistance encoded by the qnr gene and mediated by plasmid pMG252 was discovered in a clinical strain of Klebsiella… (More)
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Highly Cited
1999
Highly Cited
1999
Carbapenem activities against Pseudomonas aeruginosa: respective contributions of OprD and efflux systems.
While meropenem MICs were strongly influenced by the presence or absence of the MexAB-OprM efflux pump in both OprD-proficient… (More)
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1998
1998
The effect of reserpine, an inhibitor of multidrug efflux pumps, on the in-vitro activities of ciprofloxacin, sparfloxacin and moxifloxacin against clinical isolates of Staphylococcus aureus.
In Staphylococcus aureus, in addition to mutations in the grl and gyr gene loci, multidrug efflux pumps like NorA contribute to… (More)
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Highly Cited
1997
Highly Cited
1997
Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones.
gyrA and parC mutations have been identified inn Streptococcus pneumoniae mutants stepwise selected for resistance to… (More)
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Review
1993
Review
1993
Clinical pharmacokinetics of sparfloxacin.
Sparfloxacin is a recently developed fluoroquinolone. The drug has shown potent antimicrobial activity against a wide range of… (More)
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Highly Cited
1990
Highly Cited
1990
Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones.
The norA gene cloned from chromosomal DNA of quinolone-resistant Staphylococcus aureus TK2566 conferred relatively high… (More)
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