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sparfloxacin

Known as: sparfloxacin [Chemical/Ingredient], 5-amino-1-cyclopropyl-7-[(3R,5S)3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-quinoline-3-carboxylic acid, cis-5-Amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
A fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription. Sparfloxacin was withdrawn… 
National Institutes of Health

Related topics

Related topics

39 relations

Narrower (3)

AT 4140CI 978PD 131501
AlbuterolAmiodaroneAmiodarone hydrochlorideAstemizole

Broader (3)

Antitubercular AgentsFluoroquinolonesTopoisomerase II Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Synthesis and antibacterial activity of 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine quinolones.
Highly Cited
2003
Highly Cited
2003
Development of a long-lasting ventricular catheter impregnated with a combination of antibiotics.
Review
2003
Review
2003
Five-year analysis of Haemophilus influenzae isolates with reduced susceptibility to fluoroquinolones: prevalence results from the SENTRY antimicrobial surveillance program.
2001
2001
In vitro method for prediction of the phototoxic potentials of fluoroquinolones.
1999
1999
Antimicrobial resistance among community-acquired pneumonia isolates in Europe: First results from the SENTRY antimicrobial surveillance program 1997
Highly Cited
1998
Highly Cited
1998
Sparfloxacin vs ofloxacin in the treatment of acute bacterial exacerbations of chronic bronchitis: a multicenter, double-blind, randomized, comparative study. Sparfloxacin Multicenter ABECB Study…
STUDY OBJECTIVE Comparison of efficacy and safety of sparfloxacin vs ofloxacin for treatment of acute bacterial exacerbations of… 
Review
1996
Review
1996
Overview of electrocardiographic and cardiovascular safety data for sparfloxacin. Sparfloxacin Safety Group.
During the preclinical development of sparfloxacin, prolongation of the electrocardiographic QT interval was observed in dogs… 
1996
1996
Comparative in vitro activity of levofloxacin and ofloxacin against gram-positive bacteria.
Highly Cited
1993
Highly Cited
1993
Comparative antimycobacterial activities of the newly synthesized quinolone AM-1155, sparfloxacin, and ofloxacin
AM-1155 is a newly synthesized 6-fluoro-8-methoxy quinolone. We assessed its in vitro antimycobacterial activity using… 
Highly Cited
1991
Highly Cited
1991
Activities of sparfloxacin, azithromycin, temafloxacin, and rifapentine compared with that of clarithromycin against multiplication of Mycobacterium avium complex within human macrophages
The activities of sparfloxacin, azithromycin, temafloxacin, and rifapentine against two virulent strains of the Mycobacterium… 
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