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Comparative left ventricular dimensions in trained athletes.
Recognizing greater left ventricular mass and volume in well-trained athletes aids in interpreting values deviating from "normal" limits.
Relation between Echocardiographically Determined Left Atrial Size and Atrial Fibrillation
Left atrial size is an important factor in the development of atrial fibrillation and in determining the long term result of cardioversion, and when left atrial dimension exceeds 45 mm, cardioversion is unlikely to produce sinus rhythm that can be maintained at least six months.
Hepatotoxicity of Tyrosine Kinase Inhibitors: Clinical and Regulatory Perspectives
Post-marketing experience with drugs such as imatinib, lapatinib and sorafenib suggests that the hepatotoxic safety of all the TKIs requires diligent surveillance, and the majority of TKI approved to date are reported to induce hepatic injury.
Dose-response relation between terfenadine (Seldane) and the QTc interval on the scalar electrocardiogram: distinguishing a drug effect from spontaneous variability.
From the observed placebo variability, it is calculated that an increase in QTc of=35 msec while receiving drug therapy is likely to represent a drug effect at the 95% confidence interval.
Telavancin versus Standard Therapy for Treatment of Complicated Skin and Skin Structure Infections Caused by Gram-Positive Bacteria: FAST 2 Study
- M. Stryjewski, V. Chu, +9 authors G. Corey
- MedicineAntimicrobial Agents and Chemotherapy
- 1 March 2006
The overall incidences and severities of AEs and laboratory abnormalities were similar between the two groups, and these data support the ongoing studies assessing the efficacy and safety of telavancin in the treatment of serious gram-positive infections, particularly involving MRSA.
Cardiovascular Safety of Tyrosine Kinase Inhibitors: With a Special Focus on Cardiac Repolarisation (QT Interval)
There is now a persuasive case for a regulatory requirement to study TKIs systematically for these effects, since most of these novel drugs are studied in trials with relatively small sample sizes and approved on an expedited basis, there is also a compelling case for their effective pharmacovigilance.
Electrocardiographic Identification of Drug‐Induced QT Prolongation: Assessment by Different Recording and Measurement Methods
- N. Sarapa, J. Morganroth, +7 authors A. Moss
- MedicineAnnals of noninvasive electrocardiology : the…
- 1 January 2004
Standard and Holter‐derived 12‐lead ECGs are compared for utility in detecting sotalol‐induced QT/QTc and RR changes and manual methods were compared for precision of QT and RR interval measurement.
A definitive or thorough phase 1 QT ECG trial as a requirement for drug safety assessment.
- J. Morganroth
- MedicineJournal of electrocardiology
An approach to interpretation of the resulting ECG data from the trial and proper selection of the sample size, frequency of and method to analyze ECGs are provided.
Diagnostic accuracy of seismocardiography compared with electrocardiography for the anatomic and physiologic diagnosis of coronary artery disease during exercise testing.
- R. Wilson, V. Bamrah, J. Lindsay, M. Schwaiger, J. Morganroth
- MedicineThe American journal of cardiology
- 1 March 1993
Seismocardiography significantly improved sensitivity for the detection of anatomic and physiologic CAD and may be a clinically useful adjunct in exercise stress testing.
Mechanism and prevention of cardiac arrhythmias in chronic hemodialysis patients.
Maintenance hemodialysis patient using digoxin and with left ventricular hypertrophy have an unexpectdly high indicence of occult, potentoial serious, ventricular arrhythmias during and after he modialysis, revealed by Holter monitoring.