Topoisomerase II Inhibitors

Known as: DNA Type 2 Topoisomerase Inhibitors, Topoisomerase-II Inhibitors, DNA Topoisomerase II Inhibitors 
Any substance that inhibits topoisomerase-II, a topoisomerase that relieves torsional stress in a DNA molecule by cutting both strands of the DNA… (More)
National Institutes of Health

Papers overview

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Review
2005
Review
2005
Topoisomerase II inhibitors represent a broad class of antineoplastic agents with a wide spectrum of activity against… (More)
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2005
2005
BACKGROUND DNA topoisomerase II inhibitors and poisons are among the most efficacious drugs for the treatment of cancer… (More)
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Highly Cited
2004
Highly Cited
2004
Acetylation of histones leads to conformational changes of DNA. We have previously shown that the histone deacetylase (HDAC… (More)
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Review
2003
Review
2003
Topoisomerase II inhibitors are chemicals that inhibit a group of DNA enzymes called type II topoisomerases (topoisomerase IIs… (More)
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Review
2001
Review
2001
The epipodophyllotoxins etoposide and teniposide and other DNA topoisomerase II inhibitors including anthracyclines and… (More)
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Highly Cited
2000
Highly Cited
2000
DNA topoisomerase II is an essential nuclear enzyme that modulates DNA topology during multiple cellular processes such as DNA… (More)
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Highly Cited
1996
Highly Cited
1996
The MLL gene located at 11q23 is frequently disrupted by chromosomal translocation in a wide spectrum of newly diagnosed acute… (More)
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Highly Cited
1991
Highly Cited
1991
In order to understand the cellular events associated with cell death after the formation of topoisomerase II-DNA cleavable… (More)
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Highly Cited
1986
Highly Cited
1986
Most DNA intercalators and epipodophyllotoxins inhibit mammalian topoisomerase II by trapping the enzyme within DNA cleavage… (More)
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1986
1986
DNA intercalating drugs and the epipodophyllotoxins etoposide and teniposide interfere with the action of mammalian DNA… (More)
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