Topoisomerase II Inhibitors
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Acetylation of histones leads to conformational changes of DNA. We have previously shown that the histone deacetylase (HDAC… Expand The nuclear enzyme DNA topoisomerase II is a major target for antineoplastic agents. All topoisomerase II-directed agents are… Expand Topoisomerase II inhibitors are chemicals that inhibit a group of DNA enzymes called type II topoisomerases (topoisomerase IIs… Expand The epipodophyllotoxins etoposide and teniposide and other DNA topoisomerase II inhibitors including anthracyclines and… Expand DNA topoisomerase II is an essential nuclear enzyme that modulates DNA topology during multiple cellular processes such as DNA… Expand Infant leukemia, diagnosed in the first 12 months of life, is extremely rare in the United States; the overall annual incidence… Expand The MLL gene located at 11q23 is frequently disrupted by chromosomal translocation in a wide spectrum of newly diagnosed acute… Expand In order to understand the cellular events associated with cell death after the formation of topoisomerase II-DNA cleavable… Expand Most DNA intercalators and epipodophyllotoxins inhibit mammalian topoisomerase II by trapping the enzyme within DNA cleavage… Expand DNA intercalating drugs and the epipodophyllotoxins etoposide and teniposide interfere with the action of mammalian DNA… Expand