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Topoisomerase II Inhibitors

Known as: DNA Type 2 Topoisomerase Inhibitors, Topoisomerase-II Inhibitors, DNA Topoisomerase II Inhibitors 
Any substance that inhibits topoisomerase-II, a topoisomerase that relieves torsional stress in a DNA molecule by cutting both strands of the DNA… Expand
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
Acetylation of histones leads to conformational changes of DNA. We have previously shown that the histone deacetylase (HDAC… Expand
Review
2003
Review
2003
The nuclear enzyme DNA topoisomerase II is a major target for antineoplastic agents. All topoisomerase II-directed agents are… Expand
Review
2003
Review
2003
  • K. Hande
  • Cancer chemotherapy and biological response…
  • 2003
  • Corpus ID: 22570207
Topoisomerase II inhibitors are chemicals that inhibit a group of DNA enzymes called type II topoisomerases (topoisomerase IIs… Expand
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Review
2001
Review
2001
  • C. Felix
  • Medical and pediatric oncology
  • 2001
  • Corpus ID: 33400707
The epipodophyllotoxins etoposide and teniposide and other DNA topoisomerase II inhibitors including anthracyclines and… Expand
Highly Cited
2000
Highly Cited
2000
DNA topoisomerase II is an essential nuclear enzyme that modulates DNA topology during multiple cellular processes such as DNA… Expand
Review
2000
Review
2000
  • J. Ross
  • Proceedings of the National Academy of Sciences…
  • 2000
  • Corpus ID: 28038460
Infant leukemia, diagnosed in the first 12 months of life, is extremely rare in the United States; the overall annual incidence… Expand
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Highly Cited
1996
Highly Cited
1996
The MLL gene located at 11q23 is frequently disrupted by chromosomal translocation in a wide spectrum of newly diagnosed acute… Expand
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Highly Cited
1991
Highly Cited
1991
In order to understand the cellular events associated with cell death after the formation of topoisomerase II-DNA cleavable… Expand
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Highly Cited
1986
Highly Cited
1986
Most DNA intercalators and epipodophyllotoxins inhibit mammalian topoisomerase II by trapping the enzyme within DNA cleavage… Expand
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Highly Cited
1986
Highly Cited
1986
DNA intercalating drugs and the epipodophyllotoxins etoposide and teniposide interfere with the action of mammalian DNA… Expand
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