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Topoisomerase II Inhibitors

Known as: DNA Type 2 Topoisomerase Inhibitors, Topoisomerase-II Inhibitors, DNA Topoisomerase II Inhibitors 
Any substance that inhibits topoisomerase-II, a topoisomerase that relieves torsional stress in a DNA molecule by cutting both strands of the DNA… 
National Institutes of Health

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A 62176A 85226AclarubicinBE 10988
In Bloodchemical synthesis

Papers overview

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2017
2017
Abstract 4145: Concurrent treatment with Pim kinase inhibitor decreases alternative non-homologous end-joining repair of DNA damage induced by topoisomerase 2 inhibitors in cells with FLT3-ITD
2011
2011
Dominant lethal mutations of topoisomerase II inhibitors etoposide and merbarone in male mice: a mechanistic study
Two topoisomerase II inhibitors, etoposide and merbarone, were tested for the induction of dominant lethal mutations in male mice… 
2011
2011
induced by topoisomerase II inhibitors (see comments) Site-specific DNA cleavage within the MLL breakpoint cluster region
2007
2007
How to keep kidneys safe while shrinking tumors: the conundrum of cisplatin action.
cisplatin has been a mainstay of chemotherapy of various solid tumors for years. A significant body of investigations into its… 
2005
2005
Cyclic AMP-dependent Protein Kinase Type I Is Involved in Hypersensitivity of Human Breast Cells to Topoisomerase II Inhibitors 1
Topoisomerase II (Topo II) is an essential enzyme that catalyzes the breakage of double-strand DNA and is the target of several… 
2003
2003
Topoisomerase II inhibitors etoposide and doxorubicin induced rearrangement and fusion of AML1 gene
Objective To investigate the relationship between topoisomerase Ⅱ inhibitors and t(8;21) chromosomal translocation. Methods The… 
2000
2000
Protein-tyrosine kinase Lyn mediates apoptosis induced by topoisomerase II inhibitors in DT40 cells
1998
1998
DNA Topoisomerase II Inhibitors Enhance Random Integration of Transfected Vectors into Human Chromosomes(DNAトポイソメラーゼII阻害剤によるヒト染色体への導入ベクターの挿入促進)
1992
1992
Topoisomerase II Inhibitors: Prospects for New Antifungal Agents
The DNA of both prokaryotic and eukaryotic cells exhibits several common tertiary structures including supercoils, knots, and… 
1989
1989
Isolation of two Chinese hamster ovary cell mutants hypersensitive to topoisomerase II inhibitors and cross-resistant to peroxides.
We have isolated two Chinese hamster ovary cell lines, designated ADR-4 and ADR-5, which exhibit hypersensitivity to…