• Publications
  • Influence
Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of
TLDR
Vancomycin is a glycopeptide antibiotic that is one of the most widely used antibiotics in the United States for the treatment of serious gram-positive streptococcus aureus infections. Expand
Vancomycin therapeutic guidelines: a summary of consensus recommendations from the infectious diseases Society of America, the American Society of Health-System Pharmacists, and the Society of
TLDR
A literature review of existing evidence regarding vancomycin dosing and monitoring of serum concentrations, in addition to patient outcomes combined with expert opinion regarding the drug's pharmacokinetic, pharmacodynamic, and safety record, resulted in new recommendations for targeting and adjustment of vancomYcin therapy. Expand
Antimicrobial-drug resistance.
Since their discovery, antimicrobial drugs have proved remarkably effective for the control of bacterial infections. However, it was soon evident that bacterial pathogens were unlikely to surrenderExpand
Relationship of MIC and Bactericidal Activity to Efficacy of Vancomycin for Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia
TLDR
It is concluded that a significant risk for vancomycin treatment failure in MRSA bacteremia begins to emerge with increasing vancomYcin MICs well within the susceptible range. Expand
Linezolid resistance in a clinical isolate of Staphylococcus aureus
TLDR
An MRSA isolate resistant to linezolid is characterised that was recovered from a patient treated with this agent for dialysis-associated peritonitis. Expand
The Sanford guide to antimicrobial therapy
TLDR
The sanford guide to antimicrobial therapy – trusted infectious diseaseRecommendations for antimicrobial usage and best practices for using antimicrobial agents in clinical practice are provided. Expand
Therapeutic Monitoring of Vancomycin in Adults
TLDR
The area under the concentration‐time curve (AUC):minimum inhibitory concentration (MIC) ratio is the most useful pharmacodynamic parameter to predict vancomycin effectiveness and a target ratio of 400 or greater to eradicate S. aureus infections is suggested. Expand
Linezolid: The First Oxazolidinone Antimicrobial
TLDR
The oxazolidinones have excellent in vitro activity against all of the major gram-positive bacteria that are pathogenic in humans and have a unique mechanism of action that precludes cross-resistance with currently available agents. Expand
Emergence of Enterococcus as a significant pathogen.
  • R. Moellering
  • Medicine
  • Clinical infectious diseases : an official…
  • 1 June 1992
TLDR
Enterococci are components of the normal bowel flora of humans and other animals and have shown convincingly that they are significant nosocomial pathogens. Expand
Accessory Gene Regulator (agr) Locus in Geographically Diverse Staphylococcus aureus Isolates with Reduced Susceptibility to Vancomycin
TLDR
Findings imply that compromised agr function is advantageous to clinical isolates of S. aureus toward the development of vancomycin heteroresistance, perhaps through theDevelopment of van comycin tolerance. Expand
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