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Astemizole

Known as: Astemizolum, Astemizole [Chemical/Ingredient], 1-(P-Fluorobenzyl)-2-((1-(2-(P-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole 
A synthetic piperidinyl-benzimidazol derivative with antiallergic properties, Astemizole acts as a reversible competitive inhibitor of histamine H1… 
National Institutes of Health

Related topics

Related topics

50 relations
200 ML Fluconazole 2 MG/ML Injection24 HR Clarithromycin 500 MG Extended Release Oral TabletAllergic ConjunctivitisAstemizole:MCnc:Pt:Ser/Plas:Qn

Narrower (12)

AlermizolAsteminaEsmacenHismanal

Broader (1)

Anti-Allergic Agents

Papers overview

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2012
2012
Cytotoxic Effects of Some N-Substituted-2-Amino-1H-Benzimidazoles
The cytotoxic activity of previously synthesized is (benzimidazol-2-yl) amines was evaluated on two cancer celllines:human… 
2010
2010
Lack of appreciable species differences in nonspecific microsomal binding.
Species differences in microsomal binding were evaluated for 43 drug molecules in human, monkey, dog and rat liver microsomes… 
1996
1996
Spectrophotometric determination of astemizole by charge-transfer complex formation with chloranilic acid
A simple and sensitive spectrophotometric method for the determination of astemizole as pure substance and in dosage forms has… 
1995
1995
Determination of astemizole using iodine charge-transfer complexation and high performance liquid chromatrography
Deux methodes analytiques sont decrites pour la determination de l'astemizole. Une methode spectrophotometrique, rapide et simple… 
1993
1993
Prolonged QT interval and torsade de pointes following astemizole overdose.
A 26 year-old woman was admitted to the hospital two hours after astemizole overdose. Electrocardiograph showed a prolonged QT… 
1993
1993
Comparison of CNS adverse effects between astemizole and chlorpheniramine in children: a randomized, double-blind study.
OBJECTIVE To assess the central nervous system side effects of chlorpheniramine and astemizole in children. DESIGN Prospective… 
Review
1987
Review
1987
Primary and secondary effector cells in the pathogenesis of bronchial asthma.
The immediate and late asthmatic reactions provoked by inhaled allergens have provided useful models enabling the dissection of… 
1986
1986
The pharmacological profile of a specific, safe, effective and non-sedative anti-allergic, astemizole
In the compound 48/80 lethality test in rats, which is based on the specific activation of mast cells, astemizole was selected as… 
1985
1985
New antihistaminic N-heterocyclic 4-piperidinamines. 3. Synthesis and antihistaminic activity of N-(4-piperidinyl)-3H-imidazo[4,5-b]pyridin-2-amines.
To study the bioisosteric replacement of a 2-pyridyl ring for a phenyl nucleus in astemizole, a series of N-(4-piperidinyl)-3H… 
1985
1985
The development of a new antihistamine: astemizole.
As compared with reference antihistamines, the action of astemizole is characterized by several unusual properties: highly…