Astemizole

Known as: Astemizolum, Astemizole [Chemical/Ingredient], 1-(P-Fluorobenzyl)-2-((1-(2-(P-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole 
A synthetic piperidinyl-benzimidazol derivative with antiallergic properties, Astemizole acts as a reversible competitive inhibitor of histamine H1… (More)
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
The high cost and protracted time line of new drug discovery are major roadblocks to creating therapies for neglected diseases… (More)
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Highly Cited
2004
Highly Cited
2004
The performance of alamar blue and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) cell viability assays in a… (More)
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Highly Cited
2004
Highly Cited
2004
Ether à go-go (Eag; KV10.1) voltage-gated K+ channels have been detected in cancer cell lines of diverse origin and shown to… (More)
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Highly Cited
2003
Highly Cited
2003
The human ether-a-gogo-related gene (hERG) encodes the alpha subunit of the cardiac potassium current IKr. Several mutations in… (More)
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2002
2002
Orally administered astemizole is well absorbed but undergoes an extensive first-pass metabolism to O-desmethylastemizole… (More)
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Review
2000
Review
2000
Drug interactions occur when the efficacy or toxicity of a medication is changed by administration of another substance… (More)
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1999
1999
INTRODUCTION The selective H1-receptor antagonist astemizole (Hismanal) causes acquired long QT syndrome. Astemizole blocks the… (More)
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Review
1998
Review
1998
The novel finding that grapefruit juice can markedly augment oral drug bioavailability was based on an unexpected observation… (More)
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1995
1995
BACKGROUND Cetirizine and astemizole have been shown to be safe and effective in the treatment of patients with chronic… (More)
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Highly Cited
1995
Highly Cited
1995
We compared the cardiac electrophysiological actions of two types of H1-receptor antagonists--the piperidines, astemizole and… (More)
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