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Astemizole

Known as: Astemizolum, Astemizole [Chemical/Ingredient], 1-(P-Fluorobenzyl)-2-((1-(2-(P-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole 
A synthetic piperidinyl-benzimidazol derivative with antiallergic properties, Astemizole acts as a reversible competitive inhibitor of histamine H1… Expand
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
The high cost and protracted time line of new drug discovery are major roadblocks to creating therapies for neglected diseases… Expand
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Review
2005
Review
2005
Consistent with its highest abundance in humans, cytochrome P450 (CYP) 3A is responsible for the metabolism of about 60% of… Expand
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Highly Cited
2004
Highly Cited
2004
The performance of alamar blue and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) cell viability assays in a… Expand
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Review
2003
Review
2003
In 1966, Francois Dessertenne described a specific electrocardiographic form of polymorphic ventricular tachycardia, which he… Expand
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Highly Cited
2002
Highly Cited
2002
Orally administered astemizole is well absorbed but undergoes an extensive first-pass metabolism to O-desmethylastemizole… Expand
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Review
2000
Review
2000
Drug interactions occur when the efficacy or toxicity of a medication is changed by administration of another substance… Expand
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Highly Cited
1999
Highly Cited
1999
Electrophysiologic Effects of Astemizole Metabolites. Introduction: The selective H1‐receptor antagonist astemizole (Hismanal… Expand
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Review
1998
Review
1998
The novel finding that grapefruit juice can markedly augment oral drug bioavailability was based on an unexpected observation… Expand
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Highly Cited
1996
Highly Cited
1996
The widely used histamine receptor antagonists terfenadine and astemizole were shown to prolong the QT interval in… Expand
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Highly Cited
1995
Highly Cited
1995
We compared the cardiac electrophysiological actions of two types of H1-receptor antagonists--the piperidines, astemizole and… Expand
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