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Astemizole
Known as:
Astemizolum
, Astemizole [Chemical/Ingredient]
, 1-(P-Fluorobenzyl)-2-((1-(2-(P-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole
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A synthetic piperidinyl-benzimidazol derivative with antiallergic properties, Astemizole acts as a reversible competitive inhibitor of histamine H1…
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National Institutes of Health
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Related topics
Related topics
50 relations
200 ML Fluconazole 2 MG/ML Injection
24 HR Clarithromycin 500 MG Extended Release Oral Tablet
Allergic Conjunctivitis
Astemizole:MCnc:Pt:Ser/Plas:Qn
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Narrower (12)
Alermizol
Astemina
Esmacen
Hismanal
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Broader (1)
Anti-Allergic Agents
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Drug Repurposing from an Academic Perspective.
T. Oprea
,
J. Bauman
,
+26 authors
L. Sklar
Drug discovery today. Therapeutic strategies
2011
Corpus ID: 10830621
Highly Cited
2006
Highly Cited
2006
A clinical drug library screen identifies astemizole as an antimalarial agent
C. Chong
,
Xiaochun Chen
,
Lirong Shi
,
Jun O. Liu
,
D. Sullivan
Nature chemical biology
2006
Corpus ID: 2445698
The high cost and protracted time line of new drug discovery are major roadblocks to creating therapies for neglected diseases…
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Review
2004
Review
2004
Drug-induced prolongation of the QT interval.
D. Roden
The New England journal of medicine
2004
Corpus ID: 15251057
The single most common cause of the withdrawal or restriction of the use of marketed drugs has been QT-interval prolongation…
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Highly Cited
2004
Highly Cited
2004
Comparison of alamar blue and MTT assays for high through-put screening.
R. Hamid
,
Y. Rotshteyn
,
L. Rabadi
,
R. Parikh
,
P. Bullock
Toxicology in vitro : an international journal…
2004
Corpus ID: 2418074
Review
2003
Review
2003
Drug induced QT prolongation and torsades de pointes
Y. G. Yap
,
A. Camm
Heart
2003
Corpus ID: 438099
In 1966, Francois Dessertenne described a specific electrocardiographic form of polymorphic ventricular tachycardia, which he…
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Highly Cited
2003
Highly Cited
2003
Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia.
U. Langheinrich
,
G. Vacun
,
T. Wagner
Toxicology and applied pharmacology
2003
Corpus ID: 778636
Review
2000
Review
2000
Pharmacokinetic-Pharmacodynamic Consequences and Clinical Relevance of Cytochrome P450 3A4 Inhibition
G. Dresser
,
J. Spence
,
D. Bailey
Clinical pharmacokinetics
2000
Corpus ID: 37743328
Drug interactions occur when the efficacy or toxicity of a medication is changed by administration of another substance…
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Highly Cited
1999
Highly Cited
1999
Block of HERG Potassium Channels by the Antihistamine Astemizole and its Metabolites Desmethylastemizole and Norastemizole
Zhengfeng Zhou
,
V. Vorperian
,
Q. Gong
,
Shetuan Zhang
,
C. January
Journal of cardiovascular electrophysiology
1999
Corpus ID: 25655101
Electrophysiologic Effects of Astemizole Metabolites. Introduction: The selective H1‐receptor antagonist astemizole (Hismanal…
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Review
1999
Review
1999
Oral Montelukast, Inhaled Beclomethasone, and Placebo for Chronic Asthma
K. Malmstrom
,
G. Rodriguez-gomez
,
+5 authors
T. Reiss
Annals of Internal Medicine
1999
Corpus ID: 6397303
For patients with persistent asthma, the National Asthma Education and Prevention Program recommends the regular use of…
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Review
1998
Review
1998
Grapefruit juice-drug interactions.
D. Bailey
,
J. Malcolm
,
O. Arnold
,
J. Spence
British journal of clinical pharmacology
1998
Corpus ID: 7597296
The novel finding that grapefruit juice can markedly augment oral drug bioavailability was based on an unexpected observation…
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