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Astemizole

Known as: Astemizolum, Astemizole [Chemical/Ingredient], 1-(P-Fluorobenzyl)-2-((1-(2-(P-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole 
A synthetic piperidinyl-benzimidazol derivative with antiallergic properties, Astemizole acts as a reversible competitive inhibitor of histamine H1… Expand
National Institutes of Health

Related topics

Related topics

50 relations
200 ML Fluconazole 2 MG/ML Injection24 HR Clarithromycin 500 MG Extended Release Oral TabletAllergic ConjunctivitisAstemizole:MCnc:Pt:Ser/Plas:Qn
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Narrower (12)

AlermizolAsteminaEsmacenHismanal
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Broader (1)

Anti-Allergic Agents

Papers overview

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Highly Cited
2006
Highly Cited
2006
A clinical drug library screen identifies astemizole as an antimalarial agent
The high cost and protracted time line of new drug discovery are major roadblocks to creating therapies for neglected diseases… Expand
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Review
2005
Review
2005
Mechanism-Based Inhibition of Cytochrome P450 3A4 by Therapeutic Drugs
Consistent with its highest abundance in humans, cytochrome P450 (CYP) 3A is responsible for the metabolism of about 60% of… Expand
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Highly Cited
2004
Highly Cited
2004
Comparison of alamar blue and MTT assays for high through-put screening.
The performance of alamar blue and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) cell viability assays in a… Expand
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Review
2003
Review
2003
Drug induced QT prolongation and torsades de pointes
In 1966, Francois Dessertenne described a specific electrocardiographic form of polymorphic ventricular tachycardia, which he… Expand
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Highly Cited
2002
Highly Cited
2002
Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole.
Orally administered astemizole is well absorbed but undergoes an extensive first-pass metabolism to O-desmethylastemizole… Expand
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Review
2000
Review
2000
Pharmacokinetic-Pharmacodynamic Consequences and Clinical Relevance of Cytochrome P450 3A4 Inhibition
Drug interactions occur when the efficacy or toxicity of a medication is changed by administration of another substance… Expand
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Highly Cited
1999
Highly Cited
1999
Block of HERG Potassium Channels by the Antihistamine Astemizole and its Metabolites Desmethylastemizole and Norastemizole
Electrophysiologic Effects of Astemizole Metabolites. Introduction: The selective H1‐receptor antagonist astemizole (Hismanal… Expand
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Review
1998
Review
1998
Grapefruit juice-drug interactions.
The novel finding that grapefruit juice can markedly augment oral drug bioavailability was based on an unexpected observation… Expand
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Highly Cited
1996
Highly Cited
1996
Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole
The widely used histamine receptor antagonists terfenadine and astemizole were shown to prolong the QT interval in… Expand
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Highly Cited
1995
Highly Cited
1995
Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine.
We compared the cardiac electrophysiological actions of two types of H1-receptor antagonists--the piperidines, astemizole and… Expand
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