Astemizole

Known as: Astemizolum, Astemizole [Chemical/Ingredient], 1-(P-Fluorobenzyl)-2-((1-(2-(P-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole 
A synthetic piperidinyl-benzimidazol derivative with antiallergic properties, Astemizole acts as a reversible competitive inhibitor of histamine H1… (More)
National Institutes of Health

Related topics

Related topics

50 relations
200 ML Fluconazole 2 MG/ML Injection24 HR Clarithromycin 500 MG Extended Release Oral TabletAllergic ConjunctivitisAmprenavir
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Narrower (10)

AlermizolAsteminaEsmacenHismanal
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Broader (1)

Anti-Allergic Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
A clinical drug library screen identifies astemizole as an antimalarial agent.
The high cost and protracted time line of new drug discovery are major roadblocks to creating therapies for neglected diseases… (More)
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Highly Cited
2004
Highly Cited
2004
Comparison of alamar blue and MTT assays for high through-put screening.
The performance of alamar blue and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) cell viability assays in a… (More)
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Highly Cited
2004
Highly Cited
2004
Mechanism of Block of hEag1 K+ Channels by Imipramine and Astemizole
Ether à go-go (Eag; KV10.1) voltage-gated K+ channels have been detected in cancer cell lines of diverse origin and shown to… (More)
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Highly Cited
2003
Highly Cited
2003
Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG.
The human ether-a-gogo-related gene (hERG) encodes the alpha subunit of the cardiac potassium current IKr. Several mutations in… (More)
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2002
2002
Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole.
Orally administered astemizole is well absorbed but undergoes an extensive first-pass metabolism to O-desmethylastemizole… (More)
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Review
2000
Review
2000
Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition.
Drug interactions occur when the efficacy or toxicity of a medication is changed by administration of another substance… (More)
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1999
1999
Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole.
INTRODUCTION The selective H1-receptor antagonist astemizole (Hismanal) causes acquired long QT syndrome. Astemizole blocks the… (More)
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Review
1998
Review
1998
Grapefruit juice-drug interactions.
The novel finding that grapefruit juice can markedly augment oral drug bioavailability was based on an unexpected observation… (More)
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1995
1995
Cetirizine and astemizole therapy for chronic idiopathic urticaria: a double-blind, placebo-controlled, comparative trial.
BACKGROUND Cetirizine and astemizole have been shown to be safe and effective in the treatment of patients with chronic… (More)
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Highly Cited
1995
Highly Cited
1995
Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine.
We compared the cardiac electrophysiological actions of two types of H1-receptor antagonists--the piperidines, astemizole and… (More)
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