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Astemizole

Known as: Astemizolum, Astemizole [Chemical/Ingredient], 1-(P-Fluorobenzyl)-2-((1-(2-(P-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole 
A synthetic piperidinyl-benzimidazol derivative with antiallergic properties, Astemizole acts as a reversible competitive inhibitor of histamine H1… 
National Institutes of Health

Related topics

Related topics

50 relations
200 ML Fluconazole 2 MG/ML Injection24 HR Clarithromycin 500 MG Extended Release Oral TabletAllergic ConjunctivitisAstemizole:MCnc:Pt:Ser/Plas:Qn

Narrower (12)

AlermizolAsteminaEsmacenHismanal

Broader (1)

Anti-Allergic Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Drug Repurposing from an Academic Perspective.
Highly Cited
2006
Highly Cited
2006
A clinical drug library screen identifies astemizole as an antimalarial agent
The high cost and protracted time line of new drug discovery are major roadblocks to creating therapies for neglected diseases… 
Review
2004
Review
2004
Drug-induced prolongation of the QT interval.
  • D. Roden
  • The New England journal of medicine
  • 2004
  • Corpus ID: 15251057
The single most common cause of the withdrawal or restriction of the use of marketed drugs has been QT-interval prolongation… 
Highly Cited
2004
Highly Cited
2004
Comparison of alamar blue and MTT assays for high through-put screening.
Review
2003
Review
2003
Drug induced QT prolongation and torsades de pointes
In 1966, Francois Dessertenne described a specific electrocardiographic form of polymorphic ventricular tachycardia, which he… 
Highly Cited
2003
Highly Cited
2003
Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia.
Review
2000
Review
2000
Pharmacokinetic-Pharmacodynamic Consequences and Clinical Relevance of Cytochrome P450 3A4 Inhibition
Drug interactions occur when the efficacy or toxicity of a medication is changed by administration of another substance… 
Highly Cited
1999
Highly Cited
1999
Block of HERG Potassium Channels by the Antihistamine Astemizole and its Metabolites Desmethylastemizole and Norastemizole
Electrophysiologic Effects of Astemizole Metabolites. Introduction: The selective H1‐receptor antagonist astemizole (Hismanal… 
Review
1999
Review
1999
Oral Montelukast, Inhaled Beclomethasone, and Placebo for Chronic Asthma
For patients with persistent asthma, the National Asthma Education and Prevention Program recommends the regular use of… 
Review
1998
Review
1998
Grapefruit juice-drug interactions.
The novel finding that grapefruit juice can markedly augment oral drug bioavailability was based on an unexpected observation… 
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