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Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity.
The aim of the study is to explore the contribution of genetic factors related either to drug metabolism (cytochrome P450 2C9) or to drug target (vitamin K epoxide reductase) to variability in theExpand
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Antianginal and Antiischemic Effects of Ivabradine, an If Inhibitor, in Stable Angina: A Randomized, Double-Blind, Multicentered, Placebo-Controlled Trial
Background—Heart rate reduction should benefit patients with chronic stable angina by improving myocardial perfusion and reducing myocardial oxygen demand. This study evaluated the antianginal andExpand
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Frequency of cytochrome P450 2C9 allelic variants in the Chinese and French populations
Cytochrome P450 2C9 (CYP2C9) is a polymorphic enzyme responsible for the metabolism of different drugs with low therapeutic index such as oral anticoagulants. CYP2C9*2 and CYP2C9*3 are two singleExpand
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Digoxin pharmacokinetics and MDR1 genetic polymorphisms
BackgroundThe effect of MDR1 C3435T single nucleotide polymorphism (SNP) in exon 26 on digoxin pharmacokinetics has recently been challenged.ObjectiveTo clarify the relationships between MDR1 geneticExpand
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Pharmacokinetic‐pharmacodynamic modeling of the effects of ivabradine, a direct sinus node inhibitor, on heart rate in healthy volunteers
Ivabradine (S‐16257) is a new bradycardic agent with a direct effect on the sinus node. Its N‐dealkylated metabolite, S‐18982, has shown a bradycardic activity in animals. The aim of this trial wasExpand
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Inhibition by omeprazole of proguanil metabolism: mechanism of the interaction in vitro and prediction of in vivo results from the in vitro experiments.
Both the antimalarial prodrug proguanil and the gastric proton pump inhibitor omeprazole are substrates for cytochrome P450 (CYP)2C19 and CYP3A. However, the relative contribution of each enzyme toExpand
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Environmental and genetic factors associated with morphine response in the postoperative period
The aim of this study was to investigate the respective influence of genetic and nongenetic factors on morphine dose requirements and adverse effects after colorectal surgery.
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Pharmacokinetics and Platelet Antiaggregating Effects of Beraprost, an Oral Stable Prostacyclin Analogue, in Healthy Volunteers
Beraprost sodium (BPS) is an orally stable analogue of prostacyclin that inhibits adenylate-cyclase dependent platelet aggregation and is proposed for treatment of chronic arterial occlusion. ToExpand
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Cytochrome P-450 3A4 and 2C8 are involved in zopiclone metabolism.
Zopiclone is a widely prescribed, nonbenzodiazepine hypnotic that is extensively metabolized by the liver in humans. The aim of the present study was to identify the human cytochrome P-450 (CYP)Expand
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Clinical Pharmacokinetics of Prazosin
  • P. Jaillon
  • Medicine
  • Clinical pharmacokinetics
  • 1 July 1980
SummaryPrazosin, a quinazoline derivative, is a peripheral vasodilator used in the treatment of arterial hypertension and more recently, congestive heart failure (CHF). Prazosin is extensivelyExpand
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