• Publications
  • Influence
Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity.
TLDR
The simple genotyping of 2 single-nucleotide polymorphisms (SNPs), VKORC1 -1639G>A or 1173C>T and the CYP2C9*3 polymorphisms, could predict a high risk of overdose before initiation of anticoagulation with acenocoumarol, and provide a safer and more individualized antICOagulant therapy.
Antianginal and Antiischemic Effects of Ivabradine, an If Inhibitor, in Stable Angina: A Randomized, Double-Blind, Multicentered, Placebo-Controlled Trial
TLDR
The results suggest that ivabradine, representing a novel class of antianginal drugs, is effective and safe during 3 months of use; longer-term safety requires additional assessment.
Digoxin pharmacokinetics and MDR1 genetic polymorphisms
TLDR
It is confirmed that the MDR1 C3435T single nucleotide polymorphism (SNP) significantly affects digoxin disposition kinetics, with homozygous TT subjects presenting the highest plasma concentrations.
Frequency of cytochrome P450 2C9 allelic variants in the Chinese and French populations
TLDR
The low frequency of the CYP2C9*2 and CYP9*3 allelic variants in Chinese subjects does not justify their detection in clinical practice, unlike French Caucasians.
Dipyridamole enhances digoxin bioavailability via P‐glycoprotein inhibition
TLDR
It is postulated that dipyridamole could increase the bioavailability of digoxin, a P‐glycoprotein substrate, which is an inhibitor for the MDR1 efflux membrane transporter P‐ glycoprotein.
Pharmacokinetics and Platelet Antiaggregating Effects of Beraprost, an Oral Stable Prostacyclin Analogue, in Healthy Volunteers
TLDR
Data indicate that orally active prostacyclin BPS (40 or 60 μg) exerts its maximal antiaggregating effects between 0.5 and 1 h, and that some subjects complained of moderate postdrug absorption headaches and flushes.
Inhibition by omeprazole of proguanil metabolism: mechanism of the interaction in vitro and prediction of in vivo results from the in vitro experiments.
TLDR
In vitro studies of proguanil metabolism and interactions are predictive of in vivo situations, and it is concluded that CYP2C19 is the main enzyme responsible for proguanIL bioactivation to cycloguanil and that omeprazole inhibits this biotransformation in vitro and in vivo by inhibiting this enzyme.
Cytochrome P-450 3A4 and 2C8 are involved in zopiclone metabolism.
TLDR
Recombinant CYP2C8 had the highest enzymatic activity toward zopiclone metabolism into both its metabolites, followed by CYP 2C9 and 3A4, and CYP3A4 contributes significantly to ND-Z formation.
...
...