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Antimicrobial-modifying resistance enzymes have traditionally been class specific, having coevolved with the antibiotics they… Expand BACKGROUND
Since 2002, an epidemic of Clostridium difficile-associated-diarrhea (CDAD) associated with a high case-fatality rate… Expand Although the fluoroquinolones are presently used to treat tuberculosis primarily in cases involving resistance or intolerance to… Expand CONTEXT
Previous surveillance studies have documented increasing rates of antimicrobial resistance in US intensive care units… Expand Broad use of fluoroquinolones has been followed by emergence of resistance, which has been due mainly to chromosomal mutations in… Expand BACKGROUND
Fluoroquinolones are now recommended for the treatment of respiratory tract infections due to Streptococcus pneumoniae… Expand The fluoroquinolones are a series of synthetic antibacterial agents that are undergoing extensive investigation for both human… Expand Eight hundred and eighty-three strains of Campylobacter spp. isolated between 1982 and 1989 from human stools and poultry… Expand The fluoroquinolones, a new class of potent orally absorbed antimicrobial agents, are reviewed, considering structure, mechanisms… Expand INTRODUCTION During the past 5 to 7 years, much attention has been given to the synthesis of new 4-quinolone-3-carboxylates and… Expand