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Restricting the selection of antibiotic-resistant mutants: a general strategy derived from fluoroquinolone studies.
  • X. Zhao, K. Drlica
  • Biology, Medicine
  • Clinical infectious diseases : an official…
  • 15 September 2001
Studies with fluoroquinolones have led to a general method for restricting the selection of antibiotic-resistant mutants. The strategy is based on the use of antibiotic concentrations that requireExpand
The mutant selection window and antimicrobial resistance.
  • K. Drlica
  • Medicine, Biology
  • The Journal of antimicrobial chemotherapy
  • 1 July 2003
The mutant selection window is an antimicrobial concentration range extending from the minimal concentration required to block the growth of wild-type bacteria up to that required to inhibit theExpand
Mutant selection window hypothesis updated.
  • K. Drlica, Xilin Zhao
  • Medicine, Biology
  • Clinical infectious diseases : an official…
  • 1 March 2007
The mutant selection window hypothesis postulates that, for each antimicrobial-pathogen combination, an antimicrobial concentration range exists in which selective amplification of single-step,Expand
Quinolone-Mediated Bacterial Death
The fluoroquinolones are broad-spectrum antibacterial agents that are becoming increasingly popular as bacterial resistance erodes the effectiveness of other agents (fluoroquinolone sales accountedExpand
Effect of Fluoroquinolone Concentration on Selection of Resistant Mutants of Mycobacterium bovis BCG andStaphylococcus aureus
ABSTRACT When Mycobacterium bovis BCG and Staphylococcus aureus were plated on agar containing increasing concentrations of fluoroquinolone, colony numbers exhibited a sharp drop, followed by aExpand
Restricting the selection of antibiotic-resistant mutant bacteria: measurement and potential use of the mutant selection window.
The selection of antibiotic-resistant mutant bacteria is proposed to occur in a drug concentration range (the mutant selection window) that extends from the minimum inhibitory concentration (MIC) ofExpand
Fluoroquinolones: action and resistance.
Fluoroquinolones trap gyrase and topoisomerase IV on DNA as ternary complexes that block the movement of replication forks and transcription complexes. Studies with resistant mutants indicate thatExpand
Mechanism of fluoroquinolone action.
  • K. Drlica
  • Biology, Medicine
  • Current opinion in microbiology
  • 1 October 1999
When fluoroquinolones bind to gyrase or topoisomerase IV in the presence of DNA, they alter protein conformation. DNA cleavage results with diminished religation, so the enzymes are trapped inExpand
In Vitro Pharmacodynamic Evaluation of the Mutant Selection Window Hypothesis Using Four Fluoroquinolones against Staphylococcus aureus
ABSTRACT To study the hypothesis of the mutant selection window (MSW) in a pharmacodynamic context, the susceptibility of a clinical isolate of methicillin-resistant Staphylococcus aureus exposed toExpand
Mutant Prevention Concentrations of Fluoroquinolones for Clinical Isolates of Streptococcus pneumoniae
ABSTRACT The mutant prevention concentration (MPC) represents a threshold above which the selective proliferation of resistant mutants is expected to occur only rarely. A provisional MPC (MPCpr) wasExpand