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Microbial etiologies of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia.
  • Ronald N. Jones
  • Medicine, Biology
    Clinical infectious diseases : an official…
  • 1 August 2010
TLDR
The empirical treatment of HABP and VABP due to prevailing bacterial causes and emerging drug resistance has become more challenging and requires use of multidrug empirical treatment regimens for routine clinical practice.
Early Dissemination of NDM-1- and OXA-181-Producing Enterobacteriaceae in Indian Hospitals: Report from the SENTRY Antimicrobial Surveillance Program, 2006-2007
TLDR
Among 39 carbapenem-resistant Enterobacteriaceae isolated in 2006 and 2007 in India, 15 strains carried bla NDM-1 and 10 harbored a gene encoding a variant of the carbapENemase OXA-48, named bla OXa-181, which was disseminated in Indian health care facilities as early as 2006.
Molecular characterization of SPM-1, a novel metallo-beta-lactamase isolated in Latin America: report from the SENTRY antimicrobial surveillance programme.
TLDR
SPM-1 is a distinctly different metallo-beta-lactamase from VIM and IMP and, accordingly, represents a new subfamily of mobile metallo,beta, and lactamases, and possesses a unique loop of 23 residues that accounts for the higher molecular mass.
Molecular Characterization of a β-Lactamase Gene, blaGIM-1, Encoding a New Subclass of Metallo-β-Lactamase
TLDR
Kinetics analysis revealed that GIM-1 has no clear preference for any substrate and did not hydrolyze azlocillin, aztreonam, and the serine-β-lactamase inhibitors, and represents the fourth subclass of mobile MβL enzymes to be characterized.
Antimicrobial Susceptibility and Epidemiology of a Worldwide Collection of Chryseobacterium spp.: Report from the SENTRY Antimicrobial Surveillance Program (1997-2001)
TLDR
The highest Chryseobacterium prevalence was detected among the elderly, and the most active antimicrobials were the newer quinolones, which showed reasonable activity; vancomycin showed poor potency.
Contemporary Assessment of Antimicrobial Susceptibility Testing Methods for Polymyxin B and Colistin: Review of Available Interpretative Criteria and Quality Control Guidelines
TLDR
An evaluation of in vitro susceptibility test methods for the polymyxin class drugs confirmed continued serious testing error with the disk diffusion method, the possible need for breakpoint adjustments, and the recalculation of disk diffusion QC ranges.
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