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The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals.
TLDR
After 7.5 years, low-dose antioxidant supplementation lowered total cancer incidence and all-cause mortality in men but not in women, suggesting that supplementation may be effective in men only because of their lower baseline status of certain antioxidants, especially of beta carotene. Expand
Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation
TLDR
It is shown that human skin efficiently protects against UVB-induced DNA lesions, whereas very weak protection is afforded against UVA, which emphasize the likely role played by the UVA- induced DNA damage in skin carcinogenesis and should have consequences for photoprotection strategies. Expand
Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules.
TLDR
It is demonstrated by RT-PCR on cDNA libraries and human tissue extracts that the ZnT-8 gene is solely transcribed in the pancreas, mainly in the islets of Langerhans, and this gene is a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells. Expand
Serum concentrations of β-carotene, vitamins C and E, zinc and selenium are influenced by sex, age, diet, smoking status, alcohol consumption and corpulence in a general French adult population
TLDR
Serum antioxidant nutrient concentrations are primarily influenced by sex, age, obesity, tobacco smoking, alcohol consumption and especially dietary intake of those antioxidant nutrients. Expand
Malondialdehyde kit evaluated for determining plasma and lipoprotein fractions that react with thiobarbituric acid.
TLDR
The results reported here indicate that the malondialdehyde (MDA) kit manufactured by Sobioda complies with criteria of good analytical practices. Expand
In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion
TLDR
Data suggest that the zinc transporter ZnT-8 is a key protein for both zinc accumulation and regulation of insulin secretion in pancreatic beta cells. Expand
Effects of long-term antioxidant supplementation and association of serum antioxidant concentrations with risk of metabolic syndrome in adults.
TLDR
The experimental finding of no beneficial effects of antioxidant supplementation in a generally well-nourished population is consistent with recent reports of a lack of efficacy of antioxidant supplements, but the relations observed between the risk of MetS and baseline serum antioxidant concentrations do support the current recommendations to consume antioxidant-rich foods. Expand
Preventive effect of zinc against cadmium-induced oxidative stress in the rat testis.
TLDR
Interestingly, zinc supplementation attenuated DNA oxidation induced by Cd in the gonad and restored the testosterone level and sperm count to the levels of the control group and zinc administration was capable of reducing the elevated levels of malondialdehyde in the testis. Expand
Trace elements and lipid peroxidation abnormalities in patients with chronic renal failure.
TLDR
A defective antioxidant activity may contribute to increased peroxidative damage to cells in the course of dialysis in patients on maintenance hemodialysis. Expand
Prion infection impairs the cellular response to oxidative stress.
TLDR
This study indicates for the first time that prion infection results in an alteration of the molecular mechanisms promoting cellular resistance to reactive oxygen species and is vital for future therapeutic approaches in transmissible spongiform encephalopathies and the understanding of the function of the prion protein. Expand
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