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The Sanford guide to antimicrobial therapy
TLDR
The sanford guide to antimicrobial therapy – trusted infectious diseaseRecommendations for antimicrobial usage and best practices for using antimicrobial agents in clinical practice are provided.
Relationship of MIC and Bactericidal Activity to Efficacy of Vancomycin for Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia
TLDR
It is concluded that a significant risk for vancomycin treatment failure in MRSA bacteremia begins to emerge with increasing vancomYcin MICs well within the susceptible range.
Accessory Gene Regulator (agr) Locus in Geographically Diverse Staphylococcus aureus Isolates with Reduced Susceptibility to Vancomycin
TLDR
Findings imply that compromised agr function is advantageous to clinical isolates of S. aureus toward the development of vancomycin heteroresistance, perhaps through theDevelopment of van comycin tolerance.
Emergence of Antibiotic-Resistant Pseudomonas aeruginosa: Comparison of Risks Associated with Different Antipseudomonal Agents
TLDR
There were evident differences among antibiotics in the likelihood that their use would allow emergence of resistance in P. aeruginosa in patients treated with any of these drugs.
Outbreak of ceftazidime resistance caused by extended-spectrum beta-lactamases at a Massachusetts chronic-care facility
TLDR
Agarose gel electrophoresis of extracts from clinical isolates indicated that this outbreak arose from plasmid transmission among different strains of the family Enterobacteriaceae rather than from dissemination of a single resistant isolate.
Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombin-induced platelet microbicidal
TLDR
Isolates from patients with PB differed from those in patients with RB, in several in vitro characteristics, and it will be necessary to define how these factors might affect clinical outcome.
Galleria mellonella as a Model System To Study Acinetobacter baumannii Pathogenesis and Therapeutics
TLDR
Galleria mellonella is a relatively simple, nonmammalian model system that can be used to facilitate the in vivo study of host-pathogen interactions in A. baumannii and the efficacy of antibacterial agents.
Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2
TLDR
It is shown by chromatin immunoprecipitation, gel shift, reporter assays and elevated expression of ELA2 in vivo in neutropenic individuals that GFI1 represses ELA1, linking these two genes in a common pathway involved in myeloid differentiation.
Linezolid resistance in sequential Staphylococcus aureus isolates associated with a T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA.
TLDR
The characterization of sequential methicillin-resistant Staphylococcus aureus bloodstream isolates that developed resistance in a patient treated with a prolonged course of linezolid shows reversion to a susceptible phenotype associated with a loss of the T2500A mutation.
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