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lamotrigine
Known as:
3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
, Lamotrigina
, 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine
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A synthetic phenyltriazine with antiepileptic and analgesic properties. Lamotrigine enhances the action of gamma-aminobutyric acid, an inhibitory…
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National Institutes of Health
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Related topics
Related topics
23 relations
24 HR lamotrigine 100 MG Extended Release Oral Tablet
24 HR lamotrigine 200 MG Extended Release Oral Tablet [Lamictal]
Antidepressive Agents
Antiepileptic Agents
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Broader (5)
Anticonvulsants
Calcium Channel Blockers
Excitatory Amino Acid Antagonists
Triazines
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Narrower (1)
Lamictal
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
N-Glucuronidation of the antiepileptic drug retigabine: results from studies with human volunteers, heterologously expressed human UGTs, human liver, kidney, and liver microsomal membranes of Crigler…
J. Borlak
,
A. Gasparic
,
M. Locher
,
H. Schupke
,
R. Hermann
Metabolism: Clinical and Experimental
2006
Corpus ID: 38541587
Highly Cited
2005
Highly Cited
2005
Pregabalin Drug Interaction Studies: Lack of Effect on the Pharmacokinetics of Carbamazepine, Phenytoin, Lamotrigine, and Valproate in Patients with Partial Epilepsy
M. Brodie
,
E. Wilson
,
+8 authors
H. Bockbrader
Epilepsia
2005
Corpus ID: 13427614
Summary: Purpose: Pregabalin (PGB) is an α2‐δ ligand with demonstrated efficacy in epilepsy, neuropathic pain, and anxiety…
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Highly Cited
2003
Highly Cited
2003
Interactions of tiagabine with some antiepileptics in the maximal electroshock in mice
J. Łuszczki
,
M. Swiader
,
M. Czuczwar
,
J. Kiś
,
S. Czuczwar
Pharmacology, Biochemistry and Behavior
2003
Corpus ID: 10954435
Highly Cited
2002
Highly Cited
2002
Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia
M. Smyth
,
N. Barbaro
,
S. Baraban
Epilepsy Research
2002
Corpus ID: 15532266
Highly Cited
2002
Highly Cited
2002
Lamotrigine as adjunct to paroxetine in acute depression: a placebo-controlled, double-blind study.
C. Normann
,
B. Hummel
,
L. Schärer
,
M. Hörn
,
H. Grunze
,
J. Walden
Journal of Clinical Psychiatry
2002
Corpus ID: 2599861
BACKGROUND Mood stabilizers appear to be more potent in treating mania than depression. The anticonvulsant lamotrigine has been…
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Highly Cited
2001
Highly Cited
2001
The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K+ channels TREK-1 and TRAAK
H. J. Meadows
,
C. Chapman
,
+5 authors
A. Randall
Brain Research
2001
Corpus ID: 37830674
Highly Cited
2000
Highly Cited
2000
Homocysteine, folate, vitamin B-12 and vitamin B-6 in patients receiving antiepileptic drug monotherapy
T. Tamura
,
K. Aiso
,
K. Johnston
,
L. Black
,
E. Faught
Epilepsy Research
2000
Corpus ID: 12901252
Review
1998
Review
1998
Lamotrigine-associated anticonvulsant hypersensitivity syndrome
R. Schlienger
,
S. Knowles
,
N. Shear
Neurology
1998
Corpus ID: 46453663
We systematically reviewed and analyzed published and unpublished cases of lamotrigine-associated adverse drug reactions…
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Review
1997
Review
1997
Antiepileptic Drug Cellular Mechanisms of Action: Where Does Lamotrigine Fit In?
D. Coulter
Journal of Child Neurology
1997
Corpus ID: 24543596
Current frontline antiepileptic drugs tend to fall into several cellular mechanistic categories, and these categories often…
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Highly Cited
1992
Highly Cited
1992
Lamotrigine as an add-on drug in the management of Lennox-Gastaut syndrome.
P. Timmings
,
A. Richens
European Neurology
1992
Corpus ID: 3322217
We report our experience with lamotrigine add-on therapy in the treatment of 11 patients with Lennox-Gastaut syndrome…
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