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lamotrigine

Known as: 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine, Lamotrigina, 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine 
A synthetic phenyltriazine with antiepileptic and analgesic properties. Lamotrigine enhances the action of gamma-aminobutyric acid, an inhibitory… 
National Institutes of Health

Related topics

Related topics

23 relations
24 HR lamotrigine 100 MG Extended Release Oral Tablet24 HR lamotrigine 200 MG Extended Release Oral Tablet [Lamictal]Antidepressive AgentsAntiepileptic Agents

Broader (5)

AnticonvulsantsCalcium Channel BlockersExcitatory Amino Acid AntagonistsTriazines

Narrower (1)

Lamictal

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
N-Glucuronidation of the antiepileptic drug retigabine: results from studies with human volunteers, heterologously expressed human UGTs, human liver, kidney, and liver microsomal membranes of Crigler…
Highly Cited
2005
Highly Cited
2005
Pregabalin Drug Interaction Studies: Lack of Effect on the Pharmacokinetics of Carbamazepine, Phenytoin, Lamotrigine, and Valproate in Patients with Partial Epilepsy
Summary:  Purpose: Pregabalin (PGB) is an α2‐δ ligand with demonstrated efficacy in epilepsy, neuropathic pain, and anxiety… 
Highly Cited
2003
Highly Cited
2003
Interactions of tiagabine with some antiepileptics in the maximal electroshock in mice
Highly Cited
2002
Highly Cited
2002
Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia
Highly Cited
2002
Highly Cited
2002
Lamotrigine as adjunct to paroxetine in acute depression: a placebo-controlled, double-blind study.
BACKGROUND Mood stabilizers appear to be more potent in treating mania than depression. The anticonvulsant lamotrigine has been… 
Highly Cited
2001
Highly Cited
2001
The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K+ channels TREK-1 and TRAAK
Highly Cited
2000
Highly Cited
2000
Homocysteine, folate, vitamin B-12 and vitamin B-6 in patients receiving antiepileptic drug monotherapy
Review
1998
Review
1998
Lamotrigine-associated anticonvulsant hypersensitivity syndrome
We systematically reviewed and analyzed published and unpublished cases of lamotrigine-associated adverse drug reactions… 
Review
1997
Review
1997
Antiepileptic Drug Cellular Mechanisms of Action: Where Does Lamotrigine Fit In?
Current frontline antiepileptic drugs tend to fall into several cellular mechanistic categories, and these categories often… 
Highly Cited
1992
Highly Cited
1992
Lamotrigine as an add-on drug in the management of Lennox-Gastaut syndrome.
We report our experience with lamotrigine add-on therapy in the treatment of 11 patients with Lennox-Gastaut syndrome… 
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