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Key factors in the discovery and development of new antiepileptic drugs
TLDR
The emerging knowledge on the pathological basis of epilepsy is reviewed and how it might best be used in the design of new therapeutics is discussed.
Therapeutic Drug Monitoring of the Newer Antiepileptic Drugs
TLDR
Although routine monitoring of the newer antiepileptic drugs cannot be recommended at present, measurements of some of the drugs is undoubtedly of help with individualization of treatment in selected cases in a particular clinical setting.
Pharmacokinetic Interactions of Topiramate
TLDR
A critical review of the pharmacokinetic interactions of topiramate with old and new AEDs, an oral contraceptive, and the CNS-active drugs lithium, haloperidol, amitriptyline, risperidone, sumatriptan, propranolol and dihydroergotamine is provided.
Pharmacokinetics and drug interactions of eslicarbazepine acetate
Eslicarbazepine acetate (ESL) is a novel once‐daily antiepileptic drug (AED) approved in Europe since 2009 that was found to be efficacious and well tolerated in a phase III clinical program in adult
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