Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450.
- D. A. Erickson, G. Mather, W. Trager, R. Levy, J. Keirns
- Biology, MedicineDrug Metabolism And Disposition
- 1 December 1999
Reaction phenotyping of NVP to its four oxidative metabolites indicates that NVP is principally metabolized by CYP3A4 and CYP2B6 and that it has little potential to be involved in inhibitory drug interactions.
Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation.
Progress report on new antiepileptic drugs: A summary of the Eigth Eilat Conference (EILAT VIII)
Progress report on new antiepileptic drugs: A summary of the Ninth Eilat Conference (EILAT IX)
Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII)
Progress report on new antiepileptic drugs: a summary of the fourth Eilat conference (EILAT IV)
Metabolic Drug Interactions
The progress on metabolic drug interactions is reviewed in order to cause the attention of medical staff and take measures to cut down the frequency of ADRs caused by unreasonable metabolicDrug interactions.
New Antiepileptic Drugs: Review on Drug Interactions
- H. Hachad, I. Ragueneau-Majlessi, R. Levy
- Biology, MedicineTherapeutic Drug Monitoring
- 1 February 2002
These newer antiepileptic drugs exhibit a lower potential for drug interactions than the classic AEDs, like phenytoin, carbamazepine and valproic acid, mostly because of their pharmacokinetic characteristics.
Progress report on new antiepileptic drugs: a summary of the Sixth Eilat Conference (EILAT VI)