Excitatory Amino Acid Antagonists

Autism is a behaviorally defined neurodevelopmental disorder of unknown etiology. Mouse models with face validity to the core… Expand

Ca2+ toxicity remains the central focus of ischemic brain injury. The mechanism by which toxic Ca2+ loading of cells occurs in… Expand

Certain animal models can greatly enhance our understanding of the neurobiology of schizophrenia and can be used to predict the… Expand

Subanesthetic doses of ketamine, a noncompetitive NMDA receptor antagonist, impair prefrontal cortex (PFC) function in the rat… Expand

Gramicidin perforated-patch-clamp recordings in brain slices were used to obtain an accurate assessment of the developmental… Expand

BACKGROUND Excitotoxic damage due to excess release of neuronal glutamate is hypothesized to play a pivotal role in the… Expand

NEUROTRANSMITTER released from neurons is known to signal to neighbouring neurons and glia1–3 Here we demonstrate an additional… Expand

Glutamate has been found to play an unexpectedly important role in neuroendocrine regulation in the hypothalamus, as revealed in… Expand

Intrathecal administration of glycine (strychnine) or GABA (bicuculline) but not opioid (naloxone), adrenergic (phentolamine) or… Expand

Compounds that antagonize neuronal excitation induced by dicarboxylic amino acids were tested in two animal models of epilepsy… Expand