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Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis
It is shown that all of the soluble oligomers tested display a common conformation-dependent structure that is unique to soluble oligomer regardless of sequence, suggesting they share a common mechanism of toxicity. Expand
Exercise: a behavioral intervention to enhance brain health and plasticity
High-density oligonucleotide microarray analysis has demonstrated that, in addition to increasing levels of BDNF, exercise mobilizes gene expression profiles that would be predicted to benefit brain plasticity processes, suggesting that exercise could provide a simple means to maintain brain function and promote brain Plasticity. Expand
Exercise builds brain health: key roles of growth factor cascades and inflammation
A key mechanism mediating the broad benefits of exercise on the brain is induction of central and peripheral growth factors and growth factor cascades, which instruct downstream structural and functional change. Expand
Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain
Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) support the viability and function of many types of neurons, and are likely mediators of activity-dependent changes in the CNS.Expand
A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.
In patients with moderately severe impairment from Alzheimer's disease, treatment with selegiline or alpha-tocopherol slows the progression of disease. Expand
A microfluidic culture platform for CNS axonal injury, regeneration and transport
A microfluidic culture platform that polarizes the growth of CNS axons into a fluidically isolated environment without the use of targeting neurotrophins is described and the first evidence that presynaptic but not postsynaptic mRNA is localized to developing rat cortical and hippocampal axons is reported. Expand
Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and twoExpand
The neurobiology of learning and memory
Current progress and emerging concepts derived from the simple system approach using animal models are discussed. Expand
Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology.
It is demonstrated that tau is cleaved at D421 (DeltaTau) by executioner caspases, and therapeutics aimed at inhibiting tau caspase-cleavage may prove beneficial not only in preventing NFT formation, but also in slowing cognitive decline. Expand