Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis
It is shown that all of the soluble oligomers tested display a common conformation-dependent structure that is unique to soluble oligomer regardless of sequence, suggesting they share a common mechanism of toxicity.
Exercise: a behavioral intervention to enhance brain health and plasticity
- C. Cotman, N. Berchtold
- Biology, PsychologyTrends in Neurosciences
- 1 June 2002
Exercise builds brain health: key roles of growth factor cascades and inflammation
- C. Cotman, N. Berchtold, L. Christie
- BiologyTrends in Neurosciences
- 1 September 2007
Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease
- A. Naj, G. Jun, G. Schellenberg
- BiologyNature Genetics
- 3 April 2011
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two…
Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain
- S. Neeper, F. Gomez-Pinilla, James Choi, C. Cotman
- BiologyBrain Research
- 8 July 1996
A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.
- M. Sano, C. Ernesto, L. Thal
- Medicine, PsychologyNew England Journal of Medicine
- 24 April 1997
In patients with moderately severe impairment from Alzheimer's disease, treatment with selegiline or alpha-tocopherol slows the progression of disease.
A microfluidic culture platform for CNS axonal injury, regeneration and transport
- Anne M Taylor, M. Blurton-Jones, S. Rhee, D. Cribbs, C. Cotman, N. Jeon
- BiologyNature Methods
- 1 August 2005
A microfluidic culture platform that polarizes the growth of CNS axons into a fluidically isolated environment without the use of targeting neurotrophins is described and the first evidence that presynaptic but not postsynaptic mRNA is localized to developing rat cortical and hippocampal axons is reported.
Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology.
- R. Rissman, W. Poon, C. Cotman
- BiologyJournal of Clinical Investigation
- 1 July 2004
It is demonstrated that tau is cleaved at D421 (DeltaTau) by executioner caspases, and therapeutics aimed at inhibiting tau caspase-cleavage may prove beneficial not only in preventing NFT formation, but also in slowing cognitive decline.
Gene expression changes in the course of normal brain aging are sexually dimorphic
- N. Berchtold, D. Cribbs, C. Cotman
- Biology, PsychologyProceedings of the National Academy of Sciences
- 7 October 2008
Clear gender differences in brain aging were evident, suggesting that the brain undergoes sexually dimorphic changes in gene expression not only in development but also in later life, and that this balance is set differently in males and females.
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