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2-Amino-5-phosphonovalerate

Known as: 2-Amino-5-phosphonopentanoate, 2 Amino 5 phosphonovalerate, 2-Amino-5-phosphonovalerate [Chemical/Ingredient] 
The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA… 
National Institutes of Health

Related topics

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15 relations

Narrower (5)

2-amino-5-phosphono-3-pentenoic acid2-amino-7-phosphonoheptanoic acidCGP 39551CGP 39653

Broader (1)

Excitatory Amino Acid Antagonists
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

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Highly Cited
1999
Highly Cited
1999
A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior
Highly Cited
1995
Highly Cited
1995
Cortical Regulation of Subcortical Dopamine Release: Mediation via the Ventral Tegmental Area
Abstract: In vivo microdialysis was used to determine the extent to which ionotropic glutamate receptors in the ventral tegmental… 
Highly Cited
1992
Highly Cited
1992
Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat.
1. The role of serotonin (5‐HT) and excitatory amino‐acids (EAAs) in the activation of the neural networks (i.e. the central… 
Highly Cited
1992
Highly Cited
1992
Cholinergic excitation of GABAergic interneurons in the rat hippocampal slice.
1. Intracellular recordings were made from CA1 pyramidal cells in the rat hippocampal slice to study the cholinergic modulation… 
Highly Cited
1990
Highly Cited
1990
Differential effects of excitatory amino acid antagonists on dorsal horn nociceptive neurones in the rat
Highly Cited
1989
Highly Cited
1989
Glutamate receptor agonists increase the expression of Fos, Fra, and AP‐1 DNA binding activity in the mammalian brain
Administration of convulsant doses of Metrazole (pentylenetetrazol) and picrotoxin, as well as maximal electroshock, results in a… 
Highly Cited
1988
Highly Cited
1988
N-methyl-d-aspartate promotes the survival of cerebellar granule cells in culture
Highly Cited
1987
Highly Cited
1987
Binding of [3H]3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid to rat brain membranes: a selective, high-affinity ligand for N-methyl-D-aspartate receptors.
3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), a rigid analog of 2-amino-7-phosphonoheptanoic acid, has been reported… 
Highly Cited
1984
Highly Cited
1984
Mixed‐agonist action of excitatory amino acids on mouse spinal cord neurones under voltage clamp.
Neurones from the ventral half of mouse embryo spinal cord were grown in tissue culture and voltage clamped with two micro… 
Highly Cited
1984
Highly Cited
1984
The behavioural effects of an N-methylaspartate receptor antagonist following application to the lumbar spinal cord of conscious rats
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