2-Amino-5-phosphonovalerate

Known as: 2-Amino-5-phosphonopentanoate, 2 Amino 5 phosphonovalerate, 2-Amino-5-phosphonovalerate [Chemical/Ingredient] 
The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1981-2017
020406019812017

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15 relations

Narrower (5)

2-amino-5-phosphono-3-pentenoic acid2-amino-7-phosphonoheptanoic acidCGP 39551CGP 39653
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Broader (1)

Excitatory Amino Acid Antagonists
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
2-Amino-5-phosphonovalerate
standards characteristics
Excitatory Amino Acid Antagonists
chemical synthesis
dl-APV
2-amino-7-phosphonoheptanoic acid

Papers overview

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Highly Cited
2005
Highly Cited
2005
Blockade of NMDA receptors in the dorsomedial striatum prevents action-outcome learning in instrumental conditioning.
Although there is consensus that instrumental conditioning depends on the encoding of action-outcome associations, it is not… (More)
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Highly Cited
1997
Highly Cited
1997
Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP.
Class I metabotropic glutamate receptors (mGluRs) have been postulated to play a role in synaptic plasticity. To test the… (More)
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Highly Cited
1997
Highly Cited
1997
Propagating neuronal discharges in neocortical slices: computational and experimental study.
We studied the propagation of paroxysmal discharges in disinhibited neocortical slices by developing and analyzing a model of… (More)
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Highly Cited
1994
Highly Cited
1994
Synaptic physiology of horizontal afferents to layer I in slices of rat SI neocortex.
Layer I is a dense synaptic zone ubiquitous in cerebral cortex. Here we describe a novel in vitro preparation of rat… (More)
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Highly Cited
1992
Highly Cited
1992
Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat.
1. The role of serotonin (5-HT) and excitatory amino-acids (EAAs) in the activation of the neural networks (i.e. the central… (More)
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Highly Cited
1990
Highly Cited
1990
Disruption of experience-dependent synaptic modifications in striate cortex by infusion of an NMDA receptor antagonist.
To assess the possibility that NMDA receptors play a special role in visual cortical plasticity, the selective antagonist 2-amino… (More)
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Highly Cited
1987
Highly Cited
1987
Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices.
The effect of low extracellular Mg2+ concentration ([Mg2+]o) on neuronal activity was studied in rat hippocampal slices. After 20… (More)
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1986
1986
Phencyclidine-like behavioral effects in pigeons induced by systemic administration of the excitatory amino acid antagonist, 2-amino-5-phosphonovalerate.
A selective N-methyl-D-aspartate antagonist, DL-2-amino-5-phosphonovalerate, was found to produce PCP-like catalepsy… (More)
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Highly Cited
1982
Highly Cited
1982
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord.
The separate optical enantiomers of 2-amino-5-phosphonovalerate (APV) and 2-amino-4-phosphonobutyrate (APB) have been tested for… (More)
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Highly Cited
1981
Highly Cited
1981
2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation.
A new compound, 2-amino-5-phosphonovaleric acid (2APV) is the most potent and selective N-methyl-D-aspartate (NMDA) receptor… (More)
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