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2-Amino-5-phosphonovalerate

Known as: 2-Amino-5-phosphonopentanoate, 2 Amino 5 phosphonovalerate, 2-Amino-5-phosphonovalerate [Chemical/Ingredient] 
The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA… Expand
National Institutes of Health

Related topics

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15 relations

Narrower (5)

2-amino-5-phosphono-3-pentenoic acid2-amino-7-phosphonoheptanoic acidCGP 39551CGP 39653
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Broader (1)

Excitatory Amino Acid Antagonists
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Papers overview

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Highly Cited
2005
Highly Cited
2005
Blockade of NMDA receptors in the dorsomedial striatum prevents action–outcome learning in instrumental conditioning
Although there is consensus that instrumental conditioning depends on the encoding of action–outcome associations, it is not… Expand
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Highly Cited
1997
Highly Cited
1997
Mice Lacking Metabotropic Glutamate Receptor 5 Show Impaired Learning and Reduced CA1 Long-Term Potentiation (LTP) But Normal CA3 LTP
Class I metabotropic glutamate receptors (mGluRs) have been postulated to play a role in synaptic plasticity. To test the… Expand
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Highly Cited
1992
Highly Cited
1992
Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat.
1. The role of serotonin (5‐HT) and excitatory amino‐acids (EAAs) in the activation of the neural networks (i.e. the central… Expand
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Highly Cited
1992
Highly Cited
1992
The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury
The contribution of excitatory amino acids (EAAs) to the development of central sensitization and persistent nociception in… Expand
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Highly Cited
1990
Highly Cited
1990
Disruption of experience-dependent synaptic modifications in striate cortex by infusion of an NMDA receptor antagonist
To assess the possibility that NMDA receptors play a special role in visual cortical plasticity, the selective antagonist 2-amino… Expand
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Highly Cited
1989
Highly Cited
1989
The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor.
The selective non-competitive NMDA receptor antagonist, MK-801, potently blocked convulsions induced in the mouse by N-methyl-DL… Expand
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Highly Cited
1987
Highly Cited
1987
Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices.
The effect of low extracellular Mg2+ concentration ([Mg2+]o) on neuronal activity was studied in rat hippocampal slices. After 20… Expand
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Highly Cited
1986
Highly Cited
1986
Primary culture of identified neurons from the visual cortex of postnatal rats
We have examined the properties of neurons from the visual cortex of postnatal Long Evans rats in dissociated cell culture… Expand
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Highly Cited
1982
Highly Cited
1982
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord
The separate optical enantiomers of 2-amino-5-phosphonovalerate (APV) and 2-amino-4-phosphonobutyrate (APB) have been tested for… Expand
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Highly Cited
1981
Highly Cited
1981
2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation
A new compound, 2-amino-5-phosphonovaleric acid (2APV) is the most potent and selective N-methyl-D-aspartate (NMDA) receptor… Expand
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