2-Amino-5-phosphonovalerate

Known as: 2-Amino-5-phosphonopentanoate, 2 Amino 5 phosphonovalerate, 2-Amino-5-phosphonovalerate [Chemical/Ingredient] 
The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1981-2017
020406019812017

Papers overview

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Highly Cited
2005
Highly Cited
2005
Although there is consensus that instrumental conditioning depends on the encoding of action-outcome associations, it is not… (More)
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Highly Cited
1997
Highly Cited
1997
Class I metabotropic glutamate receptors (mGluRs) have been postulated to play a role in synaptic plasticity. To test the… (More)
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Highly Cited
1997
Highly Cited
1997
We studied the propagation of paroxysmal discharges in disinhibited neocortical slices by developing and analyzing a model of… (More)
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Highly Cited
1994
Highly Cited
1994
Layer I is a dense synaptic zone ubiquitous in cerebral cortex. Here we describe a novel in vitro preparation of rat… (More)
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Highly Cited
1992
Highly Cited
1992
1. The role of serotonin (5-HT) and excitatory amino-acids (EAAs) in the activation of the neural networks (i.e. the central… (More)
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Highly Cited
1990
Highly Cited
1990
To assess the possibility that NMDA receptors play a special role in visual cortical plasticity, the selective antagonist 2-amino… (More)
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Highly Cited
1987
Highly Cited
1987
The effect of low extracellular Mg2+ concentration ([Mg2+]o) on neuronal activity was studied in rat hippocampal slices. After 20… (More)
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1986
1986
A selective N-methyl-D-aspartate antagonist, DL-2-amino-5-phosphonovalerate, was found to produce PCP-like catalepsy… (More)
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Highly Cited
1982
Highly Cited
1982
The separate optical enantiomers of 2-amino-5-phosphonovalerate (APV) and 2-amino-4-phosphonobutyrate (APB) have been tested for… (More)
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Highly Cited
1981
Highly Cited
1981
A new compound, 2-amino-5-phosphonovaleric acid (2APV) is the most potent and selective N-methyl-D-aspartate (NMDA) receptor… (More)
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