M. Bear

Publications268
h-index99
Citations47,406
Highly Influential Citations3,201
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LTP and LTD An Embarrassment of Riches
TLDR
This work reviews those forms of LTP and LTD for which mechanisms have been most firmly established and examples are provided that show how these mechanisms can contribute to experience-dependent modifications of brain function.
Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.
  • S. Dudek, M. Bear
  • Chemistry, Medicine
    Proceedings of the National Academy of Sciences…
  • 15 May 1992
TLDR
The data suggest that synaptic depression can be triggered by prolonged NMDA receptor activation that is below the threshold for inducing synaptic potentiation, and it is proposed that this mechanism is important for the modifications of hippocampal response properties that underlie some forms of learning and memory.
The mGluR theory of fragile X mental retardation
TLDR
Loss of fragile X mental retardation protein (FMRP), the defect responsible for fragile X syndrome in humans, increases LTD in mouse hippocampus, consistent with the growing evidence that FMRP normally functions as a repressor of translation of specific mRNAs.
Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity
TLDR
It is shown that LTP and LTD reversibly modify the phosphorylation of the AMPA receptor GluR1 subunit, and that identical stimulation conditions recruit different signal-transduction pathways depending on synaptic history.
Altered synaptic plasticity in a mouse model of fragile X mental retardation
TLDR
It is shown that a form of protein synthesis-dependent synaptic plasticity, long-term depression triggered by activation of metabotropic glutamate receptors, is selectively enhanced in the hippocampus of mutant mice lacking FMRP.
Neuroscience: Exploring the Brain
Acclaimed for its clear, friendly style, excellent illustrations, leading author team, and compelling theme of exploration, Neuroscience: Exploring the Brain, 4e takes a fresh, contemporary approach…
Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.
TLDR
Local postsynaptic protein synthesis, triggered by synaptic activation of metabotropic glutamate receptors, was found to modify synaptic transmission within minutes.
Learning Induces Long-Term Potentiation in the Hippocampus
TLDR
It is found that one-trial inhibitory avoidance learning in rats produced the same changes in hippocampal glutamate receptors as induction of LTP with HFS and caused a spatially restricted increase in the amplitude of evoked synaptic transmission in CA1 in vivo.
BDNF Regulates the Maturation of Inhibition and the Critical Period of Plasticity in Mouse Visual Cortex
TLDR
It is proposed that BDNF promotes the maturation of cortical inhibition during early postnatal life, thereby regulating the critical period for visual cortical plasticity.
Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression
TLDR
It is shown that PSD-95 is regulated by the ubiquitin-proteasome pathway, and data suggest that ubiquitination of PSd-95 through an Mdm2-mediated pathway is critical in regulating AMPA receptor surface expression during synaptic plasticity.
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