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LTP and LTD An Embarrassment of Riches
LTP and LTD, the long-term potentiation and depression of excitatory synaptic transmission, are widespread phenomena expressed at possibly every excitatory synapse in the mammalian brain. It is nowExpand
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Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.
  • S. Dudek, M. Bear
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 15 May 1992
We tested a theoretical prediction that patterns of excitatory input activity that consistently fail to activate target neurons sufficiently to induce synaptic potentiation will instead cause aExpand
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The mGluR theory of fragile X mental retardation
Many of the diverse functional consequences of activating group 1 metabotropic glutamate receptors require translation of pre-existing mRNA near synapses. One of these consequences is long-termExpand
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Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity
Bidirectional changes in the efficacy of neuronal synaptic transmission, such as hippocampal long-term potentiation (LTP) and long-term depression (LTD), are thought to be mechanisms for informationExpand
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Altered synaptic plasticity in a mouse model of fragile X mental retardation
Fragile X syndrome, the most common inherited form of human mental retardation, is caused by mutations of the Fmr1 gene that encodes the fragile X mental retardation protein (FMRP). BiochemicalExpand
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Neuroscience: Exploring the Brain
Acclaimed for its clear, friendly style, excellent illustrations, leading author team, and compelling theme of exploration, Neuroscience: Exploring the Brain, 4e takes a fresh, contemporary approachExpand
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Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.
A hippocampal pyramidal neuron receives more than 10(4) excitatory glutamatergic synapses. Many of these synapses contain the molecular machinery for messenger RNA translation, suggesting that theExpand
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Learning Induces Long-Term Potentiation in the Hippocampus
Years of intensive investigation have yielded a sophisticated understanding of long-term potentiation (LTP) induced in hippocampal area CA1 by high-frequency stimulation (HFS). These efforts haveExpand
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BDNF Regulates the Maturation of Inhibition and the Critical Period of Plasticity in Mouse Visual Cortex
Maturation of the visual cortex is influenced by visual experience during an early postnatal period. The factors that regulate such a critical period remain unclear. We examined the maturation andExpand
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Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression
PSD-95 is a major scaffolding protein of the postsynaptic density, tethering NMDA- and AMPA-type glutamate receptors to signaling proteins and the neuronal cytoskeleton. Here we show that PSD-95 isExpand
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