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- Publications
- Influence
LTP and LTD An Embarrassment of Riches
- R. Malenka, M. Bear
- Psychology, Medicine
- Neuron
- 30 September 2004
LTP and LTD, the long-term potentiation and depression of excitatory synaptic transmission, are widespread phenomena expressed at possibly every excitatory synapse in the mammalian brain. It is now… Expand
Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.
We tested a theoretical prediction that patterns of excitatory input activity that consistently fail to activate target neurons sufficiently to induce synaptic potentiation will instead cause a… Expand
The mGluR theory of fragile X mental retardation
Many of the diverse functional consequences of activating group 1 metabotropic glutamate receptors require translation of pre-existing mRNA near synapses. One of these consequences is long-term… Expand
Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity
- H. Lee, M. Barbarosie, K. Kameyama, M. Bear, R. Huganir
- Medicine, Biology
- Nature
- 22 June 2000
Bidirectional changes in the efficacy of neuronal synaptic transmission, such as hippocampal long-term potentiation (LTP) and long-term depression (LTD), are thought to be mechanisms for information… Expand
Altered synaptic plasticity in a mouse model of fragile X mental retardation
- K. Huber, Sean M. Gallagher, S. Warren, M. Bear
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 21 May 2002
Fragile X syndrome, the most common inherited form of human mental retardation, is caused by mutations of the Fmr1 gene that encodes the fragile X mental retardation protein (FMRP). Biochemical… Expand
Neuroscience: Exploring the Brain
- M. Bear, B. Connors, M. Paradiso
- Psychology
- 1996
Acclaimed for its clear, friendly style, excellent illustrations, leading author team, and compelling theme of exploration, Neuroscience: Exploring the Brain, 4e takes a fresh, contemporary approach… Expand
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Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.
A hippocampal pyramidal neuron receives more than 10(4) excitatory glutamatergic synapses. Many of these synapses contain the molecular machinery for messenger RNA translation, suggesting that the… Expand
Learning Induces Long-Term Potentiation in the Hippocampus
- Jonathan R. Whitlock, A. Heynen, M. Shuler, M. Bear
- Chemistry, Medicine
- Science
- 25 August 2006
Years of intensive investigation have yielded a sophisticated understanding of long-term potentiation (LTP) induced in hippocampal area CA1 by high-frequency stimulation (HFS). These efforts have… Expand
BDNF Regulates the Maturation of Inhibition and the Critical Period of Plasticity in Mouse Visual Cortex
- Z. Huang, A. Kirkwood, +5 authors S. Tonegawa
- Medicine, Biology
- Cell
- 17 September 1999
Maturation of the visual cortex is influenced by visual experience during an early postnatal period. The factors that regulate such a critical period remain unclear. We examined the maturation and… Expand
Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression
- M. Colledge, E. Snyder, +6 authors J. D. Scott
- Biology, Medicine
- Neuron
- 30 October 2003
PSD-95 is a major scaffolding protein of the postsynaptic density, tethering NMDA- and AMPA-type glutamate receptors to signaling proteins and the neuronal cytoskeleton. Here we show that PSD-95 is… Expand