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Persistent postsurgical pain: risk factors and prevention
TLDR
Strategies for identification of patients at risk and for prevention and possible treatment of this important entity of chronic pain are outlined. Expand
Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis
TLDR
The results support a revision of the NeuPSIG recommendations for the pharmacotherapy of neuropathic pain and allow a strong recommendation for use and proposal as first-line treatment in neuropathicPain for tricyclic antidepressants, serotonin-noradrenaline reuptake inhibitors, pregabalin, and gabapentin. Expand
EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision
TLDR
This second European Federation of Neurological Societies Task Force aimed at updating the existing evidence about the pharmacological treatment of neuropathic pain since 2005. Expand
Central post-stroke pain: clinical characteristics, pathophysiology, and management
TLDR
The presence of sensory loss and signs of hypersensitivity in the painful area in patients with CPSP might indicate the dual combination of deafferentation and the subsequent development of neuronal hyperexcitability. Expand
Algorithm for neuropathic pain treatment: An evidence based proposal
TLDR
NNT and NNH are currently the best way to assess relative efficacy and safety, but the need for dichotomous data, which may have to be estimated retrospectively for old trials, and the methodological complexity of pooling data from small cross‐over and large parallel group trials, remain as limitations. Expand
Phantom limb pain: a case of maladaptive CNS plasticity?
TLDR
Evidence for putative pathophysiological mechanisms with an emphasis on central, and in particular cortical, changes is discussed and suggestions for innovative interventions aimed at alleviating phantom pain are derived. Expand
Incidence of central post-stroke pain
TLDR
The cerebrovascular lesions and neurological signs associated with the CPSP syndrome, a neuropathic pain syndrome characterized by constant or intermittent pain in a body part occurring after stroke, are characterized. Expand
EFNS guidelines on pharmacological treatment of neuropathic pain
TLDR
Evaluated trials provide level A evidence for the efficacy of tricyclic antidepressants, gabapentin, pregabalin and opioids, with a large number of class I trials, followed by topical lidocaine and the newer antidepressants venlafaxine and duloxetine. Expand
The evidence for pharmacological treatment of neuropathic pain
TLDR
Large‐scale drug trials that aim to identify possible subgroups of patients who are likely to respond to specific drugs are needed to test the hypothesis that a mechanism‐based classification may help improve treatment of the individual patients. Expand
Immediate and long-term phantom limb pain in amputees: Incidence, clinical characteristics and relationship to pre-amputation limb pain
TLDR
It is suggested that preoperative limb pain plays a role in phantom pain immediately after amputation, but probably not in late persistent phantom pain. Expand
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