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Quantitative assessment of tactile allodynia in the rat paw
Threshold measurement using the up-down paradigm, in combination with the neuropathy pain model, represents a powerful tool for analyzing the effects of manipulations of the neuropathic pain state. Expand
Chronic catheterization of the spinal subarachnoid space
Calibration experiments revealed that there was little rostro-caudal diffusion of the injectate along the spinal axis and that even for compounds such as naloxone which can rapidly permeate neural tissues, the levels which do appear in the brain are small following the spinal subarachnoid administration of the drug. Expand
Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat.
These studies indicate that NSAID have a powerful effect upon spinal nociceptive processing evoked by the s.c.p.t. injection of formalin. Expand
Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists
The lack of effect of agents having a powerful effect on somatic pain stimuli and the converse effects of glutamate receptor antagonists on the strychnine hyperesthesia at doses which do not affect the somaticPain response indicate discriminable processing systems, which resemble the clinical phenomenon observed in patients suffering from sensory dysesthesia following central and peripheral horn injury. Expand
Intrathecal minocycline attenuates peripheral inflammation‐induced hyperalgesia by inhibiting p38 MAPK in spinal microglia
Findings show that minocycline given IT produces a potent and consistent antinociception in models of tissue injury and inflammation‐evoked pain, and they provide strong support for the idea that this effect is mediated by direct inhibition of spinal microglia and subsequent activation of p38 in these cells. Expand
Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat.
NMDA antagonists by the spinal route appear to be useful therapeutic agents for chemically induced facilitated pain as well as nerve injury induced tactile allodynia. Expand
Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats
  • A. Malmberg, T. Yaksh
  • Chemistry, Medicine
  • The Journal of neuroscience : the official…
  • 1 April 1995
It is demonstrated that paw formalin injection produces spinal release of PGE2-LI corresponding to the biphasic behavioral response and that the evoked release is blocked by antinociceptive doses of COX inhibitors. Expand
Increased Sensitivity of Injured and Adjacent Uninjured Rat Primary Sensory Neurons to Exogenous Tumor Necrosis Factor-α after Spinal Nerve Ligation
It is concluded that injured and adjacent uninjured DRG neurons are sensitized to TNF after SNL, suggesting that Sensitization to endogenous TNF may be essential for the development and maintenance of neuropathic pain. Expand
Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition.
These findings demonstrate that the analgesic effects of NSAIDs can be dissociated from their anti-inflammatory actions, and are thus critical for the augmented processing of pain information at the spinal level. Expand
Spinal Phosphinositide 3-Kinase–Akt–Mammalian Target of Rapamycin Signaling Cascades in Inflammation-Induced Hyperalgesia
Findings reveal that afferent inputs trigged by peripheral inflammation initiate spinal activation of PI3K–Akt–mTOR signaling pathway, a component of which participates in neuronal circuits of facilitated pain processing. Expand