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The time course of glutamate in the synaptic cleft.
The peak concentration and rate of clearance of neurotransmitter from the synaptic cleft are important determinants of synaptic function, yet the neurotransmitter concentration time course is unknownExpand
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Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
Acidic amino acids are putative excitatory synaptic transmitters1,2, the ionic mechanism of which is not well understood. Recent studies with selective agonists and antagonists suggest that neuronesExpand
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The Incorporation of NMDA Receptors with a Distinct Subunit Composition at Nascent Hippocampal Synapses In Vitro
Activity-dependent synaptic rearrangements during CNS development require NMDA receptor activation. The control of NMDA receptor function by developmentally regulated subunit expression has beenExpand
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Desensitized states prolong GABAA channel responses to brief agonist pulses
We studied the role of desensitization at inhibitory synapses by comparing nonequilibrium GABAA channel gating with inhibitory postsynaptic currents (IPSCs). Currents activated by brief pulses ofExpand
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Nonuniform probability of glutamate release at a hippocampal synapse.
A change in the probability of neurotransmitter release (Pr) is an important mechanism underlying synaptic plasticity. Although Pr is often assumed to be the same for all terminals at a singleExpand
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Permeation and block of N‐methyl‐D‐aspartic acid receptor channels by divalent cations in mouse cultured central neurones.
1. Spinal cord and hippocampal neurones in cell culture were voltage clamped using the tight‐seal, whole‐cell recording technique. The concentration of sodium and a series of divalent cations in theExpand
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Dendrodendritic Inhibition in the Olfactory Bulb Is Driven by NMDA Receptors
At many central excitatory synapses, AMPA receptors relay the electrical signal, whereas activation of NMDA receptors is conditional and serves a modulatory function. We show here quite a differentExpand
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The physiology of excitatory amino acids in the vertebrate central nervous system
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Calcium-induced actin depolymerization reduces NMDA channel activity
Actin filaments are highly concentrated in postsynaptic densities at central excitatory synapses, but their influence on postsynaptic glutamate receptors is unknown. We tested whether actinExpand
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External Tufted Cells Drive the Output of Olfactory Bulb Glomeruli
Odors synchronize the activity of olfactory bulb mitral cells that project to the same glomerulus. In vitro, a slow rhythmic excitation intrinsic to the glomerular network persists, even in theExpand
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