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Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
Using voltage-clamp experiments on mouse spinal cord neurones, it is shown that the voltage-sensitivity of NMDA action is greatly reduced on the withdrawal of physiological concentrations (∼1 mM) of Mg2+ from the extracellular fluid, providing further evidence that Mg 2+ blocks inward current flow through ion channels linked to NMDA receptors.
The time course of glutamate in the synaptic cleft.
The time course of free glutamate predicts that dissociation contributes to the decay of the AMPA receptor-mediated postsynaptic current.
The Incorporation of NMDA Receptors with a Distinct Subunit Composition at Nascent Hippocampal Synapses In Vitro
The data indicate that the synaptic NMDA receptor complement changes quickly after synapse formation, and suggests that synapses containing predominately NR1/NR2B heteromers represent “immature” sites, whereas mature sites express NMDA receptors with a distinct, presumably triheteromeric, subunit composition.
Desensitized states prolong GABAA channel responses to brief agonist pulses
Nonuniform probability of glutamate release at a hippocampal synapse.
Release probability was measured at excitatory synapses on cultured hippocampal neurons by analysis of the progressive block of N-methyl-D-aspartate receptor-mediated synaptic currents by the irreversible open channel blocker MK-801.
Dendrodendritic Inhibition in the Olfactory Bulb Is Driven by NMDA Receptors
- N. Schoppa, J. Kinzie, Y. Sahara, T. Segerson, G. Westbrook
- BiologyThe Journal of Neuroscience
- 1 September 1998
The unique dependence of dendrodendritic inhibition on slow EPSPs generated by NMDA receptors suggests that olfactory information processing depends on long-lasting reciprocal and lateral inhibition.
The physiology of excitatory amino acids in the vertebrate central nervous system
Inactivation of NMDA channels in cultured hippocampal neurons by intracellular calcium
- P. Legendre, Christian Rosenmund, G. Westbrook
- BiologyThe Journal of neuroscience : the official…
- 1 February 1993
It is suggested that [Ca2+]i transients induce NMDA channel inactivation by binding to either the channel or a nearby regulatory protein to alter channel gating, and this mechanism may play a role in downregulation of postsynaptic calcium entry during sustained synaptic activity.
GABAergic signaling to newborn neurons in dentate gyrus.
- Linda Overstreet Wadiche, Daniel A. Bromberg, A. Bensen, G. Westbrook
- BiologyJournal of neurophysiology
- 1 December 2005
It is indicated that newborn granule cells initially receive only GABAergic synapses even in the adult, consistent with the kinetics and pharmacology.