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The time course of glutamate in the synaptic cleft.
The time course of free glutamate predicts that dissociation contributes to the decay of the AMPA receptor-mediated postsynaptic current. Expand
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
Using voltage-clamp experiments on mouse spinal cord neurones, it is shown that the voltage-sensitivity of NMDA action is greatly reduced on the withdrawal of physiological concentrations (∼1 mM) of Mg2+ from the extracellular fluid, providing further evidence that Mg 2+ blocks inward current flow through ion channels linked to NMDA receptors. Expand
The Incorporation of NMDA Receptors with a Distinct Subunit Composition at Nascent Hippocampal Synapses In Vitro
The data indicate that the synaptic NMDA receptor complement changes quickly after synapse formation, and suggests that synapses containing predominately NR1/NR2B heteromers represent “immature” sites, whereas mature sites express NMDA receptors with a distinct, presumably triheteromeric, subunit composition. Expand
Desensitized states prolong GABAA channel responses to brief agonist pulses
Reopening after GABAA receptor desensitization may enhance inhibitory synaptic transmission by prolonging the response to a brief synaptic GABA transient and underlie the expression of long-lasting components of the IPSC. Expand
Permeation and block of N‐methyl‐D‐aspartic acid receptor channels by divalent cations in mouse cultured central neurones.
Manganese both permeates and blocks the NMDA receptor channel, implying an apparent increase in PCa/PNa on lowering [Na+]o and may result from interaction of permeant ions within the channel. Expand
Nonuniform probability of glutamate release at a hippocampal synapse.
Release probability was measured at excitatory synapses on cultured hippocampal neurons by analysis of the progressive block of N-methyl-D-aspartate receptor-mediated synaptic currents by the irreversible open channel blocker MK-801. Expand
The physiology of excitatory amino acids in the vertebrate central nervous system
Calcium-induced actin depolymerization reduces NMDA channel activity
The results suggest that calcium and ATP can influence NMDA channel activity by altering the state of actin polymerization and are consistent with a proposed model in which actin filaments compartmentalize a channel regulatory protein. Expand
External Tufted Cells Drive the Output of Olfactory Bulb Glomeruli
- D. De Saint Jan, Daniela Hirnet, G. Westbrook, S. Charpak
- Biology, Medicine
- The Journal of Neuroscience
- 18 February 2009
It is proposed that ET cells act as essential drivers of glomerular output to the olfactory cortex, and mediate feedforward excitation of mitral cells within the same glomerulus. Expand
NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
It is directly demonstrated that excitatory amino acids acting at NMDA receptors on spinal cord neurones increase the intracellular Ca2+ activity, measured using the indicator dye arsenazo III, and that this is the result of Ca2- influx through NMDA receptor channels. Expand