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The glutamate/GABA‐glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer
TLDR
A main objective of this review is to endorse the view that the glutamate/GABA‐glutamine cycle must be seen as a bi‐directional transfer of not only carbon units but also nitrogen units.
Control of GluR1 AMPA Receptor Function by cAMP-Dependent Protein Kinase
TLDR
It is suggested that AMPA receptor peak response open probability can be increased by PKA through phosphorylation of GluR1 Ser845.
Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis
TLDR
It is suggested that the large increase in the content of extracellular glutamate and aspartate in the hippocampus induced by the ischemic period may be one of the causal factors in the damage to certain neurons observed after ischemia.
The Transcriptome and Metabolic Gene Signature of Protoplasmic Astrocytes in the Adult Murine Cortex
TLDR
Observations indicate that astrocytes exhibit robust oxidative metabolism in the intact adult brain and suggest a prominent contribution ofAstrocytic metabolism to functional brain imaging, including BOLD (blood-oxygen level-dependent) functional magnetic resonance imaging signals.
Glial cells in (patho)physiology
J. Neurochem. (2012) 121, 4–27.
Neuronal Soluble Factors Differentially Regulate the Expression of the GLT1 and GLAST Glutamate Transporters in Cultured Astroglia
TLDR
The results suggest that soluble neuronal factors differentially regulate the expression of GLT1 and GLAST in cultured astroglia, and further elucidation of the molecular nature of the secreted neuronal factors and corresponding signalling pathways regulating theexpression of the astroglial glutamate transporters in vitro may reveal mechanisms important for the understanding and treatment of neurological diseases.
Astrocytic Control of Biosynthesis and Turnover of the Neurotransmitters Glutamate and GABA
TLDR
This review is intended to delineate the above mentioned processes and to discuss quantitatively their relative importance in the homeostatic mechanisms responsible for the maintenance of optimal conditions for the respective neurotransmission processes to operate.
Astrocytes: Glutamate producers for neurons
TLDR
Given the commensalism that exists between neurons and glia, it may be fruitful to view brain function not just as a series of interactions between neurons, but also as aseries of interactionsbetween neurons and their collaborating glial cells.
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