1-hydroxy-3-amino-2-pyrrolidone

N-Methyl-D-aspartate (NMDA) receptors play a critical role in both development of the central nervous system and adult… Expand

N-Methyl-d-aspartate (NMDA) receptors (NRs) are ionotropic receptors activated by glutamate and the co-agonist glycine. Ethanol… Expand

Results from lesion studies show that selective damage to the temporal cortex or lateral entorhinal cortex impairs visual memory… Expand

The neuroprotective effects of (R)-HA-966 and (S)-HA-966 (3-amino-1-hydroxy-2-pyrrolidinone) were examined in an MPTP (1-methyl-4… Expand

N-Methyl-D-aspartate (NMDA)/glycine site antagonists were tested for their ability to prevent cocaine-induced convulsions and… Expand

Male Sprague-Dawley rats underwent experimentally induced cardiac arrest and resuscitation, subsequently exhibiting involuntary… Expand

Competitive and non-competitive NMDA receptor complex antagonists have been shown to be active in various models of anxiolytic… Expand

HA-966 is an antagonist at the glycine modulatory site of N-methyl-D-aspartate (NMDA) receptors. Neuroprotective effects of HA… Expand

Activation of the N-methyl-D-aspartate (NMDA) receptor complex is subject to modulation via interactions at a coupled [3H]glycine… Expand

1. In experiments examining the possibility that an excitatory amino acid may be an optic nerve transmitter in mammals… Expand