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HA-966

Known as: HA 966 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

1-hydroxy-3-amino-2-pyrrolidone

Papers overview

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Highly Cited
2002
Highly Cited
2002
Facilitation of Conditioned Fear Extinction by Systemic Administration or Intra-Amygdala Infusions of d-Cycloserine as Assessed with Fear-Potentiated Startle in Rats
NMDA receptor antagonists block conditioned fear extinction when injected systemically and also when infused directly into the… 
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Highly Cited
1999
Highly Cited
1999
Characterization of MK-801-induced behavior as a putative rat model of psychosis.
The objective of this study was to characterize the behavior induced by the N-methyl-D-aspartate receptor antagonist MK-801… 
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Highly Cited
1993
Highly Cited
1993
Lack of effect of L‐687,414 ((+)‐cis‐4‐methyl‐HA‐966)5 an NMDA receptor antagonist acting at the glycine site, on cerebral glucose metabolism and cortical neuronal morphology
1 N‐methyl‐d‐aspartate (NMDA) receptor ion channel antagonists have been reported to cause pronounced increases in cerebral… 
Highly Cited
1992
Highly Cited
1992
Stereoselective R-(+) enantiomer of HA-966 displays anxiolytic effects in rodents.
Anxiolytic agents disinhibit suppressed behaviors in rodents in preclinical models of anxiety such as the non-conditioned social… 
Highly Cited
1992
Highly Cited
1992
Antinociceptive actions of different classes of excitatory amino acid receptor antagonists in mice.
Intrathecal (i.t.) injection of the competitive and selective N-methyl-D-aspartate (NMDA) receptor antagonists DL-2-amino-5… 
Highly Cited
1990
Highly Cited
1990
Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is…
The antagonist effect of (+/-)-3-amino-1-hydroxypyrrolid-2-one (HA-966) at the N-methyl-D-aspartate (NMDA) receptor occurs… 
Review
1989
Review
1989
The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system.
'The following abbreviations have been used in the text; I3-L-ODAP, I3-N-uxalyl-L-a,l3diaminu-prupiunic acid; ACPD, Trans-l-aminu… 
Highly Cited
1989
Highly Cited
1989
HA-966 antagonizes N-methyl-D-aspartate receptors through a selective interaction with the glycine modulatory site
  • A. Foster, J. Kemp
  • The Journal of neuroscience : the official…
  • 1989
  • Corpus ID: 24441193
3-Amino-1-hydroxypyrrolid-2-one (HA-966) has been known for several years as an excitatory amino acid antagonist, acting… 
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Highly Cited
1982
Highly Cited
1982
The nature of the excitatory transmitter mediating X and Y cell inputs to the cat dorsal lateral geniculate nucleus
1. In experiments examining the possibility that an excitatory amino acid may be an optic nerve transmitter in mammals… 
Highly Cited
1971
Highly Cited
1971
1‐Hydroxy‐3‐amino‐pyrrolidone‐2 (HA‐966): a new GABA‐like compound, with potential use in extrapyramidal diseases
1 The drug HA‐966 (1‐hydroxy‐3‐amino‐pyrrolidone‐2), which chemically resembles the cyclic form of GABA, has been studied for… 
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