HA-966

Known as: HA 966 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

1-hydroxy-3-amino-2-pyrrolidone

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Glycine tranporter-1 blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in vitro and in vivo.
The N-methyl-D-aspartate (NMDA) receptor (NMDA-R) has pivotal roles in neural development, learning, memory, and synaptic… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats.
NMDA receptor antagonists block conditioned fear extinction when injected systemically and also when infused directly into the… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2001
2001
Interference with visual memory in rats following infusion of the functional NMDA receptor antagonist, HA-966, into temporal regions.
Results from lesion studies show that selective damage to the temporal cortex or lateral entorhinal cortex impairs visual memory… (More)
Is this relevant?
1997
1997
D-cycloserine blocks the effects of ethanol and HA-966 in rats tested in the elevated plus-maze.
Previous studies from our laboratory have shown gender-related behavior in rats tested in the elevated plus-maze under the… (More)
Is this relevant?
1996
1996
The glycine/NMDA receptor antagonist HA-966 impairs visual recognition memory in rhesus monkeys
Recent studies have shown that strychnine-insensitive glycine binding sites positively modulate the N-methyl-D-asparate (NMDA… (More)
Is this relevant?
1992
1992
On central muscle relaxants, strychnine-insensitive glycine receptors and two old drugs: zoxazolamine and HA-966
Zoxazolamine is in the centrally-acting muscle relaxant class of drugs, which reportedly act by decreasing CNS interneuronal… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 1
Is this relevant?
1992
1992
Stereoselective R-(+) enantiomer of HA-966 displays anxiolytic effects in rodents.
Anxiolytic agents disinhibit suppressed behaviors in rodents in preclinical models of anxiety such as the non-conditioned social… (More)
Is this relevant?
1990
1990
Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is…
The antagonist effect of (+/-)-3-amino-1-hydroxypyrrolid-2-one (HA-966) at the N-methyl-D-aspartate (NMDA) receptor occurs… (More)
Is this relevant?
1989
1989
HA-966 antagonizes N-methyl-D-aspartate receptors through a selective interaction with the glycine modulatory site.
3-Amino-1-hydroxypyrrolid-2-one (HA-966) has been known for several years as an excitatory amino acid antagonist, acting… (More)
Is this relevant?
1971
1971
1-Hydroxy-3-amino-pyrrolidone-2(HA-966): a new GABA-like compound, with potential use in extrapyramidal diseases.
1. The drug HA-966 (1-hydroxy-3-amino-pyrrolidone-2), which chemically resembles the cyclic form of GABA, has been studied for… (More)
Is this relevant?