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Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005–2009
The International League Against Epilepsy (ILAE) Commission on Classification and Terminology has revised concepts, terminology, and approaches for classifying seizures and forms of epilepsy.
Early identification of refractory epilepsy.
  • P. Kwan, M. Brodie
  • Medicine, Psychology
    The New England journal of medicine
  • 3 February 2000
TLDR
Patients who have many seizures before therapy or who have an inadequate response to initial treatment with antiepileptic drugs are likely to have refractory epilepsy.
Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies
TLDR
It is proposed as a testable hypothesis that drug resistant epilepsy is defined as failure of adequate trials of two tolerated, appropriately chosen and used antiepileptic drug schedules to achieve sustained seizure freedom.
Drug-resistant epilepsy.
TLDR
A review examines how this diagnosis should be established and how to recognize pseudoresistance and explains possible mechanisms of drug-resistant epilepsy and presents treatment strategies.
Patterns of treatment response in newly diagnosed epilepsy
TLDR
Most patients with newly diagnosed epilepsy had a constant course which could usually be predicted early and the chance of seizure freedom declined with successive drug regimens, most markedly from the first to the third and among patients with localization-related epilepsies.
Potential Role of Drug Transporters in the Pathogenesis of Medically Intractable Epilepsy
TLDR
This hypothesis is supported by the findings of elevated expression of efflux transporters in epileptic foci in patients with drug‐resistant epilepsy, induction of expression by seizures in animal models, and experimental evidence that some commonly used AEDs are substrates.
Effectiveness of First Antiepileptic Drug
TLDR
The interaction among efficacy, tolerability, and overall effectiveness of the first antiepileptic drug (AED) in patients with newly diagnosed epilepsy is investigated.
Combined analysis of risk factors for SUDEP
Purpose:  To pool data from four published case–control studies of sudden unexpected death in epilepsy (SUDEP) with live controls, to increase the power to determine risk factors.
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