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ILAE Official Report: A practical clinical definition of epilepsy
TLDR
A revised definition of epilepsy brings the term in concordance with common use for individuals who either had an age‐dependent epilepsy syndrome but are now past the applicable age or who have remained seizure‐free for the last 10 years and off antiseizure medicines for at least the last 5 years.
ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology
The International League Against Epilepsy (ILAE) Classification of the Epilepsies has been updated to reflect our gain in understanding of the epilepsies and their underlying mechanisms following the
Antiepileptic drugs—best practice guidelines for therapeutic drug monitoring: A position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies
TLDR
Evidence from nonrandomized studies and everyday clinical experience does indicate that measuring serum concentrations of old and new generation antiepileptic drugs (AEDs) can have a valuable role in guiding patient management provided that concentrations are measured with a clear indication and are interpreted critically, taking into account the whole clinical context.
ILAE Treatment Guidelines: Evidence‐based Analysis of Antiepileptic Drug Efficacy and Effectiveness as Initial Monotherapy for Epileptic Seizures and Syndromes
Summary:  Purpose: To assess which antiepileptic medications (AEDs) have the best evidence for long‐term efficacy or effectiveness as initial monotherapy for patients with newly diagnosed or
Clinically relevant drug interactions with antiepileptic drugs.
  • E. Perucca
  • Medicine
    British journal of clinical pharmacology
  • 1 March 2006
TLDR
Some patients with difficult-to-treat epilepsy benefit from combination therapy with two or more antiepileptic drugs (AEDs), and pharmacodynamic interactions involving AEDs have not been well characterized, but their understanding is important for a more rational approach to combination therapy.
Rufinamide: Clinical pharmacokinetics and concentration–response relationships in patients with epilepsy
TLDR
Rufinamide is a new, orally active antiepileptic drug (AED), which has been found to be effective in the treatment of partial seizures and drop attacks associated with the Lennox‐Gastaut syndrome and a positive correlation has been identified between reduction in seizure frequency and steady‐state plasma ruf inamide concentrations.
Lennox-Gastaut syndrome: a consensus approach on diagnosis, assessment, management, and trial methodology
TLDR
The main issues with regard to the diagnosis and treatment options available are discussed and the importance of a comprehensive approach to the assessment and management of this syndrome is highlighted.
Pharmacological and Therapeutic Properties of Valproate
TLDR
Valproate is generally regarded as a first-choice agent for most forms of idiopathic and symptomatic generalised epilepsies, and prescription of a broad-spectrum drug such as valproate has clear advantages in this situation.
Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes
TLDR
Although ethosuximide and valproic acid now have level A efficacy/effectiveness evidence as initial monotherapy for children with absence seizures, there continues to be an alarming lack of well designed, properly conducted epilepsy RCTs for patients with generalized seizures/epilepsies and in children in general.
Epilepsy: new advances
TLDR
The lives of most people with epilepsy continue to be adversely affected by gaps in knowledge, diagnosis, treatment, advocacy, education, legislation, and research and Concerted actions to address these challenges are urgently needed.
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