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erbB-2 Receptor

Known as: Proto Oncogene Protein HER 2, Receptor, ErbB-2, Proto-Oncogene Protein HER-2 
A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and… 
National Institutes of Health

Related topics

Related topics

30 relations

Narrower (9)

111In-benzyl-DTPA-ZHER2:342ERBB2 protein, humanGD5 protein, recombinantHER-2/neu intracellular domain protein
ERBB2 geneERBB2 wt AlleleEpidermal Growth Factor ReceptorHER-2-neu peptide vaccine

Broader (1)

Receptor Protein-Tyrosine Kinases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2000
Highly Cited
2000
Oncogenic Signals of HER-2/neu in Regulating the Stability of the Cyclin-dependent Kinase Inhibitor p27*
Overexpression and activation of HER-2/neu, a proto-oncogene, play a pivotal role in cancer formation. Strong expression of HER-2… 
Highly Cited
1997
Highly Cited
1997
Disruption of local retinoid‐mediated gene expression accompanies abnormal development in the mammalian olfactory pathway
We have evaluated the role of retinoid signaling in the early development of the olfactory epithelium and olfactory bulb. When… 
Highly Cited
1995
Highly Cited
1995
C-erbB-2 gene amplification: a molecular marker in recurrent bladder tumors?
C-erbB-2 gene amplification and protein overexpression have been implicated as prognostic markers for patients with recurrent… 
Highly Cited
1992
Highly Cited
1992
Platelet endothelial cell adhesion molecule, PECAM‐1, modulates cell migration
Cell migration is an important process in such phenomena as growth, development, and wound healing. The control of cell migration… 
Highly Cited
1990
Highly Cited
1990
Immunohistochemical evaluation of c-erbB-2 oncogene expression in ductal carcinoma in situ and atypical ductal hyperplasia of the breast.
Cases of ductal carcinoma in situ (DCIS) and atypical ductal hyperplasia (ADH) of the breast were examined for expression of the… 
Highly Cited
1990
Highly Cited
1990
Transcriptional repression of the neu protooncogene by the adenovirus 5 E1A gene products.
Amplification/overexpression of the human neu protooncogene has been frequently found in human primary breast and ovarian cancers… 
Highly Cited
1989
Highly Cited
1989
Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor
Highly Cited
1986
Highly Cited
1986
Immunoreactivity for a calmodulin-dependent protein kinase is selectively increased in macaque striate cortex after monocular deprivation.
Immunocytochemical methods were used to localize type II Ca2+/calmodulin-dependent protein kinase in the macaque primary visual… 
Highly Cited
1985
Highly Cited
1985
Oligosaccharide structures of isolated human colonic mucin species.
Purified human colonic mucin contains six distinct components which may be separated by DEAE-cellulose chromatography. Past… 
Highly Cited
1983
Highly Cited
1983
Transcriptional activation of an unrearranged and untranslocated c-myc oncogene by translocation of a C lambda locus in Burkitt.
We have studied somatic cell hybrids between mouse myeloma cells and IARC-BL2 Burkitt lymphoma human cells carrying a t(8;22… 
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