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Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The importance of ECM remodeling to cancer is… Expand The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard… Expand PURPOSE
Triple-negative breast cancer (TNBC) is defined by the lack of estrogen receptor (ER), progesterone receptor (PR), and… Expand Since their isolation in the early 1990s, members of the Hedgehog family of intercellular signaling proteins have come to be… Expand The overexpression in tumor cells of (proto)-oncogenic receptor tyrosine kinases such as epidermal growth factor receptor (EGFR… Expand Treatment of SKBr3 human breast carcinoma cells with the benzoquinoid ansamycin, geldanamycin, rapidly depletes p185c-erbB-2… Expand TRANSDUCTION of a mitogenic signal from the cell membrane to the nucleus involves the adapter proteins SHC and Grb2, which… Expand Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration. A 145… Expand A novel potential cell surface receptor of the tyrosine kinase gene family has been identified and characterized by molecular… Expand We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA… Expand