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erbB-2 Receptor

Known as: Proto Oncogene Protein HER 2, Receptor, ErbB-2, Proto-Oncogene Protein HER-2 
A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and… Expand
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The importance of ECM remodeling to cancer is… Expand
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Highly Cited
2009
Highly Cited
2009
The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard… Expand
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Highly Cited
2008
Highly Cited
2008
PURPOSE Triple-negative breast cancer (TNBC) is defined by the lack of estrogen receptor (ER), progesterone receptor (PR), and… Expand
Review
2001
Review
2001
Since their isolation in the early 1990s, members of the Hedgehog family of intercellular signaling proteins have come to be… Expand
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Highly Cited
1997
Highly Cited
1997
The overexpression in tumor cells of (proto)-oncogenic receptor tyrosine kinases such as epidermal growth factor receptor (EGFR… Expand
Highly Cited
1996
Highly Cited
1996
Treatment of SKBr3 human breast carcinoma cells with the benzoquinoid ansamycin, geldanamycin, rapidly depletes p185c-erbB-2… Expand
Highly Cited
1996
Highly Cited
1996
TRANSDUCTION of a mitogenic signal from the cell membrane to the nucleus involves the adapter proteins SHC and Grb2, which… Expand
Highly Cited
1991
Highly Cited
1991
Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration. A 145… Expand
Highly Cited
1985
Highly Cited
1985
A novel potential cell surface receptor of the tyrosine kinase gene family has been identified and characterized by molecular… Expand
Highly Cited
1985
Highly Cited
1985
We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA… Expand