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A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes.
Preferential homing of naive lymphocytes to secondary lymphoid organs is thought to involve the action of chemokines, yet no chemokine has been shown to have either the expression pattern or theExpand
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Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome
To understand the system of secreted proteins and receptors involved in cell-cell signaling, we produced a comprehensive set of recombinant secreted proteins and the extracellular domains ofExpand
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Structural and functional diversity in the FGF receptor multigene family.
Publisher Summary The fibroblast growth factors (FGFs) constitute a family of closely related polypeptide mitogens. There are seven members of this family, identified on the basis of amino acidExpand
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A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1
Secondary lymphoid organs (spleen, lymph nodes and Peyer's patches) are divided into compartments, such as B-cell zones (follicles) and T-cell zones, which provide specialized environments forExpand
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The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor.
The fms-like tyrosine kinase (Flt) is a transmembrane receptor in the tyrosine kinase family. Expression of flt complementary DNA in COS cells conferred specific, high-affinity binding of vascularExpand
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Functional overlap but differential expression of CSF‐1 and IL‐34 in their CSF‐1 receptor‐mediated regulation of myeloid cells
CSF‐1 is broadly expressed and regulates macrophage and osteoclast development. The action and expression of IL‐34, a novel CSF‐1R ligand, were investigated in the mouse. As expected, huIL‐34Expand
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Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis.
The caspase-3 (CPP32, apopain, YAMA) family of cysteinyl proteases has been implicated as key mediators of apoptosis in mammalian cells. Gelsolin was identified as a substrate for caspase-3 byExpand
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Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse.
Fibroblast growth factors (FGFs) can influence the growth and differentiation of cultured cells derived from neuroectoderm, ectoderm or mesenchyme. The FGFs interact with a family of at least fourExpand
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Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/β-catenin signaling is activated in human colon tumors
Genetic studies have identified mutations in key regulators of the Wnt/β-catenin pathway in a variety of cancers, most frequently in colon cancers. However, whether the pathway is activated inExpand
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Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase.
Phosphatidylinositol (Pl)-3 kinase is one of many enzymes stimulated by growth factors. A constitutively activated mutant, p110, that functions independently of growth factor stimulation wasExpand
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