Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition
- B. Zhou, Jiong Deng, +4 authors M. Hung
- Biology, Medicine
- Nature Cell Biology
- 1 October 2004
The phenotypic changes of increased motility and invasiveness of cancer cells are reminiscent of the epithelial–mesenchymal transition (EMT) that occurs during embryonic development. Snail, a… Expand
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.
The ErbB2-targeting antibody, trastuzumab (Herceptin), has remarkable therapeutic efficacy in certain patients with ErbB2-overexpressing tumors. The overall trastuzumab response rate, however, is… Expand
Nuclear localization of EGF receptor and its potential new role as a transcription factor
- Shiaw-Yih Lin, Keishi Makino, +5 authors M. Hung
- Biology, Medicine
- Nature Cell Biology
- 26 September 2001
Epidermal growth factor receptor (EGFR) has been detected in the nucleus in many tissues and cell lines. However, the potential functions of nuclear EGFR have largely been overlooked. Here we… Expand
Requirement for neuregulin receptor erbB2 in neural and cardiac development
THE receptor erbB2/neu is a member of the epidermal growth factor receptor (EGFR or erbB) family that also includes erbB3 and erbB41. Amplification of the erbB2/neu gene is found in many cancer types… Expand
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
- B. Zhou, Y. Liao, W. Xia, Y. Zou, B. Spohn, M. Hung
- Biology, Medicine
- Nature Cell Biology
- 1 November 2001
HER-2/neu amplification or overexpression can make cancer cells resistant to apoptosis and promotes their growth. p53 is crucial in regulating cell growth and apoptosis, and is often mutated or… Expand
Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene…
- H. Lo, Sheng-chieh Hsu, +6 authors M. Hung
- Medicine, Biology
- Cancer research
- 1 October 2007
Aberrant epidermal growth factor receptor (EGFR) signaling is a major cause of tumor progression and metastasis; the underlying mechanisms, however, are not well understood. In particular, it remains… Expand
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
- K. Stemke-Hale, A. González-Angulo, +19 authors B. Hennessy
- Biology, Medicine
- Cancer research
- 1 August 2008
Phosphatidylinositol 3-kinase (PI3K)/AKT pathway aberrations are common in cancer. By applying mass spectroscopy-based sequencing and reverse-phase protein arrays to 547 human breast cancers and 41… Expand
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
- Jer-Yen Yang, C. S. Zong, +23 authors M. Hung
- Biology, Medicine
- Nature Cell Biology
- 1 February 2008
The RAS–ERK pathway is known to play a pivotal role in differentiation, proliferation and tumour progression. Here, we show that Erk downregulates Forkhead box O 3a (FOXO3a) by directly interacting… Expand
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
- B. Zhou, Y. Liao, W. Xia, B. Spohn, Mong-Hong Lee, M. Hung
- Chemistry, Medicine
- Nature Cell Biology
- 1 March 2001
Amplification or overexpression of HER-2/neu in cancer cells confers resistance to apoptosis and promotes cell growth. The cellular localization of p21Cip1/WAF1 has been proposed to be critical… Expand
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
Beta-catenin is upregulated in many human cancers and considered to be an oncogene. Hepatocellular carcinoma (HCC) is one of the most prevalent human malignancies, and individuals who are chronic… Expand