Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
- G. Calin, C. Dumitru, C. Croce
- BiologyProceedings of the National Academy of Sciences…
- 14 November 2002
Detailed deletion and expression analysis shows that miR15 and miR16 are located within a 30-kb region of loss in CLL, and that both genes are deleted or down-regulated in the majority (≈68%) of CLL cases.
miR-15 and miR-16 induce apoptosis by targeting BCL2.
- A. Cimmino, G. Calin, C. Croce
- BiologyProceedings of the National Academy of Sciences…
- 27 September 2005
It is demonstrated thatmiR-15a and miR-16-1 expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs negatively regulate BCL2 at a posttranscriptional level and are natural antisense B cl2 interactors that could be used for therapy of Bcl1-overexpressing tumors.
A microRNA expression signature of human solid tumors defines cancer gene targets
- S. Volinia, G. Calin, C. Croce
- BiologyProceedings of the National Academy of Sciences…
- 3 February 2006
The results indicate that miRNAs are extensively involved in cancer pathogenesis of solid tumors and support their function as either dominant or recessive cancer genes.
MicroRNA gene expression deregulation in human breast cancer.
- M. Iorio, M. Ferracin, C. Croce
- BiologyCancer Research
- 15 August 2005
It is shown that, compared with normal breast tissue, miRNAs are also aberrantly expressed in human breast cancer, and the overall miRNA expression could clearly separate normal versus cancer tissues, with the most significantly deregulated mi RNAs being mir-125b, mir-145, mir -21, and mir-155.
MicroRNA signatures in human cancers
MiRNA-expression profiling of human tumours has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment and has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein-coding genes involved in cancer.
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers.
- G. Calin, C. Sevignani, C. Croce
- BiologyProceedings of the National Academy of Sciences…
- 2 March 2004
These data provide a catalog of miR genes that may have roles in cancer and argue that the full complement of miRs in a genome may be extensively involved in cancers.
Modulation of miR-155 and miR-125b Levels following Lipopolysaccharide/TNF-α Stimulation and Their Possible Roles in Regulating the Response to Endotoxin Shock1
- E. Tili, J. Michaille, C. Croce
- BiologyJournal of Immunology
- 15 October 2007
The data suggest that the LPS/TNF-α-dependent regulation of miR-155 and miR -125b may be implicated in the response to endotoxin shock, thus offering new targets for drug design.
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis.
- N. Yanaihara, N. Caplen, C. Harris
- BiologyCancer Cell
- 1 March 2006
A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia.
- G. Calin, M. Ferracin, C. Croce
- Biology, MedicineNew England Journal of Medicine
- 27 October 2005
A unique microRNA signature is associated with prognostic factors and disease progression in CLL, and a germ-line mutation in the miR-16-1-miR-15a primary precursor caused low levels of microRNA expression in vitro and in vivo and was associated with deletion of the normal allele.
MicroRNA-133 controls cardiac hypertrophy
- A. Carè, D. Catalucci, G. Condorelli
- BiologyNature Network Boston
- 1 May 2007
The data show thatmiR-133, and possibly miR-1, are key regulators of cardiac hypertrophy, suggesting their therapeutic application in heart disease.
...
...