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Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
TLDR
Detailed deletion and expression analysis shows that miR15 and miR16 are located within a 30-kb region of loss in CLL, and that both genes are deleted or down-regulated in the majority (≈68%) of CLL cases. Expand
miR-15 and miR-16 induce apoptosis by targeting BCL2.
TLDR
It is demonstrated thatmiR-15a and miR-16-1 expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs negatively regulate BCL2 at a posttranscriptional level and are natural antisense B cl2 interactors that could be used for therapy of Bcl1-overexpressing tumors. Expand
A microRNA expression signature of human solid tumors defines cancer gene targets
TLDR
The results indicate that miRNAs are extensively involved in cancer pathogenesis of solid tumors and support their function as either dominant or recessive cancer genes. Expand
MicroRNA gene expression deregulation in human breast cancer.
TLDR
It is shown that, compared with normal breast tissue, miRNAs are also aberrantly expressed in human breast cancer, and the overall miRNA expression could clearly separate normal versus cancer tissues, with the most significantly deregulated mi RNAs being mir-125b, mir-145, mir -21, and mir-155. Expand
MicroRNA signatures in human cancers
TLDR
MiRNA-expression profiling of human tumours has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment and has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein-coding genes involved in cancer. Expand
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers.
TLDR
These data provide a catalog of miR genes that may have roles in cancer and argue that the full complement of miRs in a genome may be extensively involved in cancers. Expand
Modulation of miR-155 and miR-125b Levels following Lipopolysaccharide/TNF-α Stimulation and Their Possible Roles in Regulating the Response to Endotoxin Shock1
TLDR
The data suggest that the LPS/TNF-α-dependent regulation of miR-155 and miR -125b may be implicated in the response to endotoxin shock, thus offering new targets for drug design. Expand
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis.
TLDR
Results indicate that miRNA expression profiles are diagnostic and prognostic markers of lung cancer. Expand
MicroRNA-133 controls cardiac hypertrophy
TLDR
The data show thatmiR-133, and possibly miR-1, are key regulators of cardiac hypertrophy, suggesting their therapeutic application in heart disease. Expand
A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia.
TLDR
A unique microRNA signature is associated with prognostic factors and disease progression in CLL, and a germ-line mutation in the miR-16-1-miR-15a primary precursor caused low levels of microRNA expression in vitro and in vivo and was associated with deletion of the normal allele. Expand
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