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decitabine

Known as: Deoxyazacytidine, 2'-deoxy-5-azacytidine, AzadC compound 
A cytidine antimetabolite analogue with potential antineoplastic activity. Decitabine incorporates into DNA and inhibits DNA methyltransferase… 
National Institutes of Health

Related topics

Related topics

18 relations

Broader (4)

Antimetabolites, AntineoplasticAzacitidineEnzyme InhibitorsTeratogens
DNADNA Methylation InhibitionDNA Modification MethylasesNCIt Antineoplastic Agent Terminology

Narrower (3)

DacogenNSC 127716decitabine mesylate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Azacytidine impairs NK cell reactivity while decitabine augments NK cell responsiveness toward stimulation
Azacytidine and decitabine are approved for treatment of acute myeloid leukemias and myelodysplastic syndromes. While clinical… 
Highly Cited
2009
Highly Cited
2009
The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history
Esophageal squamous cell carcinomas (ESCCs) tend to have multiple primary lesions, and it is believed that they arise from… 
Highly Cited
2007
Highly Cited
2007
Epigenetic combination therapy as a tumor‐selective treatment approach for hepatocellular carcinoma
Innovative epigenetic therapeutics comprise histone deacetylase inhibitors (HDAC‐I) and demethylating agents (DA). It was… 
Highly Cited
2005
Highly Cited
2005
Antimitogenic and chemosensitizing effects of the methylation inhibitor zebularine in ovarian cancer
Deoxycytosine methylation within CpG islands of tumor suppressor genes plays a prominent role in the development and progression… 
Highly Cited
2004
Highly Cited
2004
The Tumor Suppressor Gene WWOX at FRA16D Is Involved in Pancreatic Carcinogenesis
Purpose: WWOX (WW domain containing oxidoreductase) is a tumor suppressor gene that maps to the common fragile site FRA16D. We… 
Highly Cited
2001
Highly Cited
2001
Identification and characterization of differentially methylated CpG islands in pancreatic carcinoma.
To identify CpG islands differentially methylated in pancreatic adenocarcinoma, we used methylated CpG island amplification (MCA… 
Highly Cited
2001
Highly Cited
2001
Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma
Aberrant methylation of CpG islands within promoter regions is associated with transcriptional inactivation of various tumor… 
Highly Cited
2001
Highly Cited
2001
Extended dynamic clamp: controlling up to four neurons using a single desktop computer and interface
Highly Cited
2001
Highly Cited
2001
Elevation of breast carcinoma Nm23-H1 metastasis suppressor gene expression and reduced motility by DNA methylation inhibition.
We hypothesize that elevation of Nm23-H1 expression in micrometastatic breast cancer cells may inhibit their metastatic… 
Highly Cited
1998
Highly Cited
1998
Independent induction of senescence by p16INK4a and p21CIP1 in spontaneously immortalized human fibroblasts.
In this work, we address the question of whether replicative senescence can be induced in immortal nontumorigenic human… 
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