decitabine

Known as: Deoxyazacytidine, 2'-deoxy-5-azacytidine, AzadC compound 
A cytidine antimetabolite analogue with potential antineoplastic activity. Decitabine incorporates into DNA and inhibits DNA methyltransferase… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Acute lymphoblastic leukemia (ALL) is the second most common acute leukemia in adults, with an incidence of over 6500 cases per… (More)
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Highly Cited
2016
Highly Cited
2016
BACKGROUND The molecular determinants of clinical responses to decitabine therapy in patients with acute myeloid leukemia (AML… (More)
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Highly Cited
2012
Highly Cited
2012
PURPOSE This multicenter, randomized, open-label, phase III trial compared the efficacy and safety of decitabine with treatment… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Glioblastoma multiforme (GBM) is an invariably fatal central nervous system tumor despite treatment with surgery… (More)
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Highly Cited
2007
Highly Cited
2007
Epithelial ovarian cancer (EOC) is the sixth most common cancer in women worldwide and, despite advances in detection and… (More)
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Highly Cited
2007
Highly Cited
2007
Epigenetic therapy with hypomethylating drugs is now the standard of care in myelodysplastic syndrome (MDS). Response rates… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Aberrant DNA methylation, which results in leukemogenesis, is frequent in patients with myelodysplastic syndromes (MDS… (More)
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Highly Cited
2004
Highly Cited
2004
Decitabine (5-aza-2'-deoxycytidine) inhibits DNA methylation and has dual effects on neoplastic cells, including the reactivation… (More)
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Highly Cited
2002
Highly Cited
2002
p16 and p15, 2 inhibitors of cyclin-dependent kinases, are frequently hypermethylated in hematologic neoplasias. Decitabine, or 5… (More)
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Highly Cited
1994
Highly Cited
1994
Mutational inactivation and allelic loss of the von Hippel-Lindau (VHL) gene appear to be causal events for the majority of… (More)
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