Dacogen
National Institutes of Health
Papers overview
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Aberrant DNA hypermethylation within promoter regions and subsequent gene silencing are near universal hallmarks of human cancer…
The cytidine analog 5-azacytidine (5-aza, Vidaza) and its deoxyribonucleoside analog 5-aza-2′-deoxycytidine (decitabine, Dacogen…
Myelodysplastický syndrom (MDS) je heterogenni skupina klonalnich onemocněni krvetvorne kmenove buňky, ktera se vyznacuje…
A 60-year-old woman with squamous cell carcinoma in the right lung was successfully treated with four cycles of combination…
Boumber and Issa provide a useful review of the development of agents that target the epigenome—primarily DNA methyltransferase…
Current Therapy for Acute Myeloid Leukemia Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults…
OBJECTIVE
Treatment with the DNA demethylating drug 5-aza-2'-deoxycytidine (Dacogen; DAC) increased fetal hemoglobin and F cells…
Normal cell development and function is dependent upon controlled gene expression. DNA methylation is an epigenetic modification…