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Hypermethylation of multiple genes in pancreatic adenocarcinoma.

It is concluded that many pancreatic carcinomas hypermethylate a small percentage of genes, whereas a subset of pancreatic adenocarcinomas displays a CIMP+ phenotype.
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STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas.

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Epstein-Barr virus in gastric carcinoma with lymphoid stroma. Special reference to its detection by the polymerase chain reaction and in situ hybridization in 99 tumors, including a morphologic…

The presence of EBV association in GCLS was characterized by the above morphologic features, including mild cellular pleomorphism, rare mitoses, a marked degree of lymphoid stroma, and mild fibrosis.
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Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma.

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K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China.

The genetic alterations in biliary tract cancers are dependent on the tumor subsite, histology, and age of onset and are associated with prognosis.
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Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation.

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Genetic Polymorphisms of XRCC1, Alcohol Consumption, and the Risk of Colorectal Cancer in Japan

There is additional evidence that individuals with the XRCC1 399Gln/Gln genotype have an increased risk of colorectal cancer, and that XR CC1 polymorphisms have an important role in coloreCTal cancer risk associated with alcohol consumption or gene-gene interaction.
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Intraductal papillary mucinous neoplasms of the pancreas associated with so-called "mucinous ductal ectasia". Histochemical and immunohistochemical analysis of 29 cases.

The results of both the histological and immunohistochemical studies suggested the possibility of a sequential change from nonpapillary and papillary hyperplasia, via adenoma, to carcinoma in intraductal papillary-mucinous neoplasms associated with mucinous ductal ectasia, thus enabling the surgeon to select the most appropriate surgical procedure.
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Aberrant methylation of CpG islands in intraductal papillary mucinous neoplasms of the pancreas.

It is suggested that de novo methylation of multiple CpG islands is one of the critical pathways that contributes to the malignant progression of IPMNs.
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Diagnosing Pancreatic Cancer Using Methylation Specific PCR Analysis

The aim of this study was to determine the utility of detecting methylated ppENK and p16 in pancreatic juice by methylation specific PCR as a marker of pancreatic adenocarcinoma. Pancreatic juice…
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