T. Ushijima

Publications456
h-index71
Citations17,544
Highly Influential Citations507
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Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer
View on Elsevier
Detection and interpretation of altered methylation patterns in cancer cells
TLDR
This work has shown that methylation alterations in DNA-methylation patterns are associated with many human tumour types and the development of new tumour suppressors and diagnostic markers based on these patterns is a good place to start.
View on Nature
Chemical genomic screening for methylation‐silenced genes in gastric cancer cell lines using 5‐aza‐2′‐deoxycytidine treatment and oligonucleotide microarray
TLDR
A metastasis suppressor gene, MTSS1, was located in a genomic region with frequent loss of heterozygosity (8q22), and was expressed abundantly in the normal gastric mucosa, suggesting its role in gastric carcinogenesis.
View on Wiley
Focus on gastric cancer.
View on PubMed
A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory
TLDR
The observations indicate that Oct‐1‐binding followed by CpG demethylation are key events in the epigenetic regulation of IL2 expression and may act as a memory of the regulatory event.
View on Wiley
Frequent PTPRK–RSPO3 fusions and RNF43 mutations in colorectal traditional serrated adenoma
TLDR
It is demonstrated that TSAs frequently harbour genetic alterations that lead to WNT pathway activation, in addition to BRAF and KRAS mutations, which are characteristic genetic features of TSAs.
View on Wiley
High Levels of Aberrant DNA Methylation in Helicobacter pylori–Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk
TLDR
It was indicated that H. pylori infection potently induces methylation of CGIs to various degrees, and methylation levels of specific CGIs seemed to reflect gastric cancer risk in H.pylori–negative individuals.
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DNA methylation of microRNA genes in gastric mucosae of gastric cancer patients: Its possible involvement in the formation of epigenetic field defect
TLDR
Methylation levels of three miRNA genes contributed to the formation of a field defect for gastric cancers, in addition to that of protein‐coding genes, and no difference was observed between intestinal and diffuse histological types.
View on Wiley
The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery
View on Elsevier
Hereditary diffuse gastric cancer: updated clinical practice guidelines.
View on PubMed
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