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Detection and interpretation of altered methylation patterns in cancer cells
TLDR
This work has shown that methylation alterations in DNA-methylation patterns are associated with many human tumour types and the development of new tumour suppressors and diagnostic markers based on these patterns is a good place to start.
Chemical genomic screening for methylation‐silenced genes in gastric cancer cell lines using 5‐aza‐2′‐deoxycytidine treatment and oligonucleotide microarray
TLDR
A metastasis suppressor gene, MTSS1, was located in a genomic region with frequent loss of heterozygosity (8q22), and was expressed abundantly in the normal gastric mucosa, suggesting its role in gastric carcinogenesis.
Focus on gastric cancer.
A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory
TLDR
The observations indicate that Oct‐1‐binding followed by CpG demethylation are key events in the epigenetic regulation of IL2 expression and may act as a memory of the regulatory event.
Frequent PTPRK–RSPO3 fusions and RNF43 mutations in colorectal traditional serrated adenoma
TLDR
It is demonstrated that TSAs frequently harbour genetic alterations that lead to WNT pathway activation, in addition to BRAF and KRAS mutations, which are characteristic genetic features of TSAs.
High Levels of Aberrant DNA Methylation in Helicobacter pylori–Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk
TLDR
It was indicated that H. pylori infection potently induces methylation of CGIs to various degrees, and methylation levels of specific CGIs seemed to reflect gastric cancer risk in H.pylori–negative individuals.
DNA methylation of microRNA genes in gastric mucosae of gastric cancer patients: Its possible involvement in the formation of epigenetic field defect
TLDR
Methylation levels of three miRNA genes contributed to the formation of a field defect for gastric cancers, in addition to that of protein‐coding genes, and no difference was observed between intestinal and diffuse histological types.
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