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Tumor Necrosis Factors

Known as: TNFSF Protein, Necrosis Factors, Tumor, tumor necrosis factor (unspecified) 
A family of proteins that were originally identified by their ability to cause NECROSIS of NEOPLASMS. Their necrotic effect on cells is mediated… 
National Institutes of Health

Related topics

Related topics

40 relations
A-Tumor Necrosis Fact SerPl-mCncApoptosis Regulatory ProteinsC1QTNF8 geneCachexia

Broader (4)

Blood ProteinsCytotoxinGlycoproteinsMonokines

Narrower (4)

TASONERMINTNF protein, humanTNFSF12 protein, humanTumor Necrosis Factor-alpha

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Oxidative Stress Mediates Tumor Necrosis Factor-&agr;–Induced Mitochondrial DNA Damage and Dysfunction in Cardiac Myocytes
Background—Tumor necrosis factor-&agr; (TNF-&agr;) and angiotensin II (Ang II) are implicated in the development and further… 
Review
2003
Review
2003
Apo2L/TRAIL and its death and decoy receptors
AbstractApo2 ligand or tumour necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) is one of the several members of… 
Highly Cited
1996
Highly Cited
1996
Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin 10 production during human endotoxemia.
Short-term preexposure of mononuclear cells to epinephrine inhibits LPS-induced production of TNF, whereas preexposure for 24 h… 
Highly Cited
1995
Highly Cited
1995
Tumor necrosis factor soluble receptors in patients with various degrees of congestive heart failure.
BACKGROUND Tumor necrosis factor alpha (TNF-alpha) increases in patients with severe congestive heart failure (CHF) and cachexia… 
Highly Cited
1993
Highly Cited
1993
Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia
Because of its ability to efficiently inhibit in vitro cytokine production by activated macrophages, we hypothesized that… 
Highly Cited
1992
Highly Cited
1992
Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.
Tumor necrosis factor alpha (TNF alpha), a primary mediator of systemic responses to sepsis and infection, can be injurious to… 
Highly Cited
1991
Highly Cited
1991
The two different receptors for tumor necrosis factor mediate distinct cellular responses.
The individual roles of the murine type 1 and type 2 tumor necrosis factor (TNF) receptors (TNF-R1 and TNF-R2) were investigated… 
Highly Cited
1987
Highly Cited
1987
Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice
The toxic properties of human recombinant tumor necrosis factor (TNF) were investigated in mice made hypersensitive to endotoxin… 
Highly Cited
1985
Highly Cited
1985
Human tumor necrosis factor. Production, purification, and characterization.
Human tumor necrosis factor (TNF) was purified to homogeneity from serum-free tissue culture supernatants of the HL-60… 
Highly Cited
1984
Highly Cited
1984
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin
Human tumour necrosis factor has about 30% homology in its amino acid sequence with lymphotoxin, a lymphokine that has similar… 
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