Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

@article{Pennica1984HumanTN,
  title={Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin},
  author={D. Pennica and G. Nedwin and J. S. Hayflick and P. Seeburg and R. Derynck and M. Palladino and W. Kohr and B. Aggarwal and D. Goeddel},
  journal={Nature},
  year={1984},
  volume={312},
  pages={724-729}
}
Human tumour necrosis factor has about 30% homology in its amino acid sequence with lymphotoxin, a lymphokine that has similar biological properties. Recombinant tumour necrosis factor can be obtained by expression of its complementary DNA in Escherichia coli and induces the haemorrhagic necrosis of transplanted methylcholanthrene-induced sarcomas in syngeneic mice. 
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