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TNFSF12 protein, human

Known as: TNF-Related Weak Inducer of Apoptosis, APO3/DR3 Ligand, Tumor Necrosis Factor Ligand Superfamily Member 12 
Tumor necrosis factor ligand superfamily member 12 (249 aa, ~27 kDa) is encoded by the human TNFSF12 gene. This protein plays a role in the positive… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
TWEAK (TNF-like weak inducer of apoptosis) is a TNF superfamily member implicated in several mechanisms. Although fibroblast… Expand
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Highly Cited
2006
Highly Cited
2006
The TNF superfamily cytokine TWEAK induces mesangial cells, podocytes, and endothelial cells to secrete pro-inflammatory… Expand
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Highly Cited
2003
Highly Cited
2003
Fn14 is a growth-factor-inducible immediate-early-response gene encoding a 102-amino-acid type I transmembrane protein. The human… Expand
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Highly Cited
2002
Highly Cited
2002
TWEAK, a member of the TNF family, induces cell death in some tumor cell lines, but also induces proliferation of endothelial… Expand
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Highly Cited
2002
Highly Cited
2002
Angiogenic regulators modulate endothelial cell functions, including proliferation, migration, secretion, and adhesion, through… Expand
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Highly Cited
2002
Highly Cited
2002
Human tumour necrosis factor (TNF)-like weak inducer of apoptosis (hTWEAK) and two anti-hTWEAK mAbs were tested for their ability… Expand
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Highly Cited
2002
Highly Cited
2002
TWEAK is a new TNF family member with proinflammatory and proliferative effects on different cell types, mediated by the recently… Expand
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Highly Cited
2000
Highly Cited
2000
Astrocytes exert many active roles in brain homeostasis, potentially including the regulation of immune reactions. They possess a… Expand
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Highly Cited
1999
Highly Cited
1999
TWEAK is a recently cloned novel member of the TNF ligand family. Here we show that soluble TWEAK is sufficient to induce… Expand
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Highly Cited
1997
Highly Cited
1997
The members of the tumor necrosis factor (TNF) family play pivotal roles in the regulation of the immune system. Here we describe… Expand
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