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CD14 is required for MyD88-independent LPS signaling
The recessive mutation 'Heedless' (hdl) was detected in third-generation N-ethyl-N-nitrosourea–mutated mice that showed defective responses to microbial inducers. Macrophages from HeedlessExpand
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Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel
Allergies to nickel (Ni2+) are the most frequent cause of contact hypersensitivity (CHS) in industrialized countries. The efficient development of CHS requires both a T lymphocyte-specific signal andExpand
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R‐form LPS, the master key to the activation ofTLR4/MD‐2‐positive cells
Lipopolysaccharide (endotoxin, LPS) is a major recognition marker for the detection of gram‐negative bacteria by the host and a powerful initiator of the inflammatory response to infection. Using S‐Expand
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Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity
Allergic contact hypersensitivity (CHS) is a T cell–mediated inflammatory skin disease. Interleukin (IL)-12 is considered to be important in the generation of the allergen-specific T cell response.Expand
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Modification of the silver staining technique to detect lipopolysaccharide in polyacrylamide gels.
A silver staining method used routinely for detecting bacterial lipopolysaccharide (LPS) in sodium dodecyl sulfate-polyacrylamide gels (C. Tsai and E. Frasch, Anal. Biochem. 119:115-119, 1982)Expand
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Toll-Like Receptor 4 Contributes to Efficient Control of Infection with the Protozoan Parasite Leishmania major
ABSTRACT The essential role of Toll-like receptors (TLR) in innate immune responses to bacterial pathogens is increasingly recognized, but very little is known about the role of TLRs in host defenseExpand
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Dose-dependent effects of endotoxin on human sleep.
The role of the central nervous system in the host response to infection and inflammation and modulation of these responses by the hypothalamic-pituitary-adrenal system are well established. InExpand
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Differential Contribution of Toll-Like Receptors 4 and 2 to the Cytokine Response to Salmonella enterica Serovar Typhimurium and Staphylococcus aureus in Mice
ABSTRACT The contribution of murine Toll-like receptors 2 and 4 (TLR2 and -4, respectively) to cytokine induction by heat-killed bacteria was analyzed in vitro and in vivo. Gram-negative bacteriaExpand
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RELATION BETWEEN ESCHERICHIA COLI R(ROUGH)-FORMS IN GUT, LIPID A IN LIVER, AND PRIMARY BILIARY CIRRHOSIS
Since antimitochondrial antibodies (AMA) specific to primary biliary cirrhosis (PBC) recognise enterobacterial proteins and can be induced by R(rough)-mutants of enterobacteriaceae a study was doneExpand
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Lipid A, the endotoxic center of bacterial lipopolysaccharides: relation of chemical structure to biological activity.
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