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TNF protein, human

Known as: TNF-A, TNFSF2 protein, human, TNF-2 protein, human 
Tumor necrosis factor (233 aa, ~26 kDa) is encoded by the human TNF gene. This protein is involved in the induction of cytokine expression, the… 
National Institutes of Health

Related topics

Related topics

46 relations
Adipocytokine Signaling PathwayAngiogenic ProcessApoptosisApoptosis Promoter

Broader (2)

Tumor Necrosis Factor-alphaTumor Necrosis Factors

Papers overview

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Highly Cited
2010
Highly Cited
2010
Involvement of Histone H3 Lysine 9 (H3K9) Methyltransferase G9a in the Maintenance of HIV-1 Latency and Its Reactivation by BIX01294*
Elucidating the mechanism of human immunodeficiency virus, type 1 (HIV-1) provirus transcriptional silencing in latently infected… 
Highly Cited
2005
Highly Cited
2005
Disruption of tumor necrosis factor-alpha gene diminishes the development of atherosclerosis in ApoE-deficient mice.
Inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha) have been implicated in atherogenesis. However, the… 
Highly Cited
2004
Highly Cited
2004
Coordinated Redistribution of Leukocyte LFA-1 and Endothelial Cell ICAM-1 Accompany Neutrophil Transmigration
The leukocyte integrin lymphocyte function-associated antigen 1 (LFA-1) and its endothelial ligand intercellular adhesion… 
Highly Cited
2003
Highly Cited
2003
Cellular Cholesterol Depletion Triggers Shedding of the Human Interleukin-6 Receptor by ADAM10 and ADAM17 (TACE)*
Interleukin-6 (IL-6) activates cells by binding to the membrane-bound IL-6 receptor (IL-6R) and subsequent formation of a… 
Highly Cited
2003
Highly Cited
2003
Oxidative Stress Mediates Tumor Necrosis Factor-&agr;–Induced Mitochondrial DNA Damage and Dysfunction in Cardiac Myocytes
Background—Tumor necrosis factor-&agr; (TNF-&agr;) and angiotensin II (Ang II) are implicated in the development and further… 
Highly Cited
2002
Highly Cited
2002
A Phosphotyrosine-dependent Protein Interaction Screen Reveals a Role for Phosphorylation of Caveolin-1 on Tyrosine 14
Caveolin-1 is a substrate for nonreceptor tyrosine kinases including Src, Fyn, and Abl. To investigate the function of caveolin-1… 
Highly Cited
2001
Highly Cited
2001
Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state.
Tumor necrosis factor (TNF)-alpha causes insulin resistance on glucose uptake in fetal brown adipocytes. We explored the… 
Highly Cited
2000
Highly Cited
2000
Tumor Necrosis Factor-&agr; Promotes In Vitro Calcification of Vascular Cells via the cAMP Pathway
BackgroundVascular calcification is an ectopic calcification that commonly occurs in atherosclerosis. Because tumor necrosis… 
Highly Cited
1999
Highly Cited
1999
Limb and skin abnormalities in mice lacking IKKalpha.
The gene encoding inhibitor of kappa B (IkappaB) kinase alpha (IKKalpha; also called IKK1) was disrupted by gene targeting… 
Highly Cited
1998
Highly Cited
1998
Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme.
Tumor necrosis factor-alpha (TNFalpha) is a cytokine that induces protective inflammatory reactions and kills tumor cells but… 
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