T. Okamoto

Publications295
h-index70
Citations17,281
Highly Influential Citations580
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Co-purification and Direct Interaction of Ras with Caveolin, an Integral Membrane Protein of Caveolae Microdomains
TLDR
It is shown that caveolin interacts with another well characterized signal transducer, Ras, and that recombinant overexpression of caveolin in intact cells is sufficient to functionally recruit a nonfarnesylated mutant of Ras onto membranes, overcoming the normal requirement for lipid modification of Ras.
Expression of Caveolin-3 in Skeletal, Cardiac, and Smooth Muscle Cells
TLDR
A novel monoclonal antibody probe is generated that recognizes the unique N-terminal region of caveolin-3, but not other members of the caveolin gene family, and co-immunoprecipitates with antibodies directed against dystrophin suggesting that they are physically associated as a discrete complex.
Molecular Cloning of Caveolin-3, a Novel Member of the Caveolin Gene Family Expressed Predominantly in Muscle (*)
TLDR
The molecular cloning and expression of a third member of the caveolin gene family, caveolin-3, is reported and it is suggested that other as yet unknown caveolin family members are likely to exist and may be expressed in a regulated or tissue-specific fashion.
Caveolin‐mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo
Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection.
Identification, sequence, and expression of caveolin-2 defines a caveolin gene family.
Caveolin, a 21- to 24-kDa integral membrane protein, is a principal component of caveolae membranes. Caveolin interacts directly with heterotrimeric guanine nucleotide binding proteins (G proteins)…
Involvement of Histone H3 Lysine 9 (H3K9) Methyltransferase G9a in the Maintenance of HIV-1 Latency and Its Reactivation by BIX01294*
TLDR
Evidence is presented that histone H3 Lys9 (H3K9) methyltransferase G9a is responsible for transcriptional repression of HIV-1 by promoting repressive dimethylation at H3K 9 and for the maintenance of viral latency.
Alzheimer amyloid protein precursor complexes with brain GTP-binding protein Go
TLDR
The cytoplasmic APP sequence His 657–Lys 676 shows a specific Go-activating function and is necessary for complex formation, suggesting that APP is a receptor coupled to Go and that abnormal APP–Go signalling is involved in the Alzheimer's disease process.
Expression of caveolin-1 and -2 in differentiating PC12 cells and dorsal root ganglion neurons: caveolin-2 is up-regulated in response to cell injury.
TLDR
The expression of caveolin-1 and -2 in differentiating PC12 cells and dorsal root ganglion (DRG) neurons is demonstrated by using mono-specific antibody probes to demonstrate that neuronal cells express caveolins.
Akt-Mediated Survival of Oligodendrocytes Induced by Neuregulins
TLDR
The present data suggest that the survival function of heregulin is mediated through the PI-3 kinase/Akt pathway in cells in the oligodendrocyte lineage and that the Akt pathway may be quite important for survival of cells in this lineage.
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