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Pathogen Recognition and Innate Immunity
New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity. Expand
Toll-like receptor signalling
Rapid progress that has recently improved the understanding of the molecular mechanisms that mediate TLR signalling is reviewed. Expand
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Recent advances that have been made by research into the role of TLR biology in host defense and disease are described. Expand
Pattern Recognition Receptors and Inflammation
The role of PRRs, their signaling pathways, and how they control inflammatory responses are discussed. Expand
Guidelines for the use and interpretation of assays for monitoring autophagy
These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. Expand
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
Intracellular double-stranded RNA (dsRNA) is a chief sign of replication for many viruses. Host mechanisms detect the dsRNA and initiate antiviral responses. In this report, we identify retinoic acidExpand
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
It is found that RIG-I is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus and Japanese encephalitis virus, whereas MDA5 is critical for picornavirus detection. Expand
A Toll-like receptor recognizes bacterial DNA
It is shown that cellular response to CpG DNA is mediated by a Toll-like receptor, TLR9, and vertebrate immune systems appear to have evolved a specific Toll- like receptor that distinguishes bacterial DNA from self-DNA. Expand
Toll-like receptors: critical proteins linking innate and acquired immunity
Evidence is accumulating that the signaling pathways associated with each TLR are not identical and may, therefore, result in different biological responses. Expand
Toll-like receptors in innate immunity.
Toll-like receptors-mediated activation of innate immunity controls not only host defense against pathogens but also immune disorders, and the involvement of TLR-mediated pathways in autoimmune and inflammatory diseases has been proposed. Expand