Tumor Necrosis Factor-alpha

Known as: Cachectin Tumor Necrosis Factor, Tumor Necrosis Factor-alpha [Chemical/Ingredient], Tumor Necrosis Factor alpha 
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines… (More)

Topic mentions per year

Topic mentions per year

1964-2017
020040060019642017

Papers overview

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Highly Cited
2008
Highly Cited
2008
The inhibitor of apoptosis (IAP) proteins are a family of anti-apoptotic regulators found in viruses and metazoans. c-IAP1 and c… (More)
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Highly Cited
2006
Highly Cited
2006
Activation of NF-kappaB and autophagy are two processes involved in the regulation of cell death, but the possible cross-talk… (More)
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Highly Cited
2005
Highly Cited
2005
The proinflammatory cytokine tumor necrosis factor-alpha (TNFalpha) causes a rapid exocytosis of AMPA receptors in hippocampal… (More)
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Highly Cited
2000
Highly Cited
2000
Nuclear factor kappaB (NF-kappaB)/Rel transcription factors are key regulators of a variety of genes involved in immune and… (More)
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Highly Cited
1998
Highly Cited
1998
In view of the recent demonstration that obesity in animals and humans is associated with an increase in tumor necrosis factor… (More)
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Highly Cited
1998
Highly Cited
1998
The signaling pathways that couple tumor necrosis factor-alpha (TNFalpha) receptors to functional, especially inflammatory… (More)
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Highly Cited
1997
Highly Cited
1997
Nitric oxide (NO) and tumor necrosis factor-alpha (TNFalpha) play important roles in the pathogenesis of liver disease during… (More)
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Highly Cited
1996
Highly Cited
1996
In the present study, it was shown that physiologically relevant levels of the proinflammatory cytokine TNFalpha induced… (More)
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Highly Cited
1993
Highly Cited
1993
OBJECTIVE To evaluate the safety and efficacy of a chimeric monoclonal antibody to tumor necrosis factor alpha (TNF alpha) in the… (More)
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Highly Cited
1988
Highly Cited
1988
Synovial fluids from 6 of 12 patients with rheumatoid arthritis (RA) and from 3 of 11 patients with reactive arthritis contained… (More)
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