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Tumor Necrosis Factor-alpha

Known as: Cachectin Tumor Necrosis Factor, Tumor Necrosis Factor-alpha [Chemical/Ingredient], Tumor Necrosis Factor alpha 
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines… 
National Institutes of Health

Related topics

Related topics

33 relations
A-Tumor Necrosis Fact SerPl-mCncCachexiaIn BloodNecrosis

Narrower (14)

F 4168F 4614LK-805PEG-modified tumor necrosis factor-alpha

Broader (2)

MonokinesTumor Necrosis Factors

Papers overview

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Highly Cited
2008
Highly Cited
2008
Associations of adiponectin, resistin, and tumor necrosis factor-alpha with insulin resistance.
CONTEXT Adipose tissue-derived adipokines may contribute to insulin resistance. OBJECTIVE We tested the hypothesis that… 
Highly Cited
2000
Highly Cited
2000
Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis.
OBJECTIVE To verify the hypothesis that in rheumatoid arthritis (RA), tumor necrosis factor alpha (TNFalpha) plays a critical… 
Highly Cited
1999
Highly Cited
1999
Tissue expression and immunolocalization of tumor necrosis factor-alpha in postinfarction dysfunctional myocardium.
BACKGROUND Tumor necrosis factor-alpha (TNF-alpha) is markedly elevated in advanced heart failure. It is not known whether tissue… 
Review
1999
Review
1999
Etanercept Therapy in Rheumatoid Arthritis
Rheumatoid arthritis occurs in approximately 1% of the adult population and is associated with progressive joint destruction… 
Review
1996
Review
1996
The tumor necrosis factor ligand and receptor families.
Tumor necrosis factor (TNF) and lymphotoxin-α were isolated more than 10 years ago, on the basis of their ability to kill tumor… 
Highly Cited
1996
Highly Cited
1996
Decrease in cellularity and expression of adhesion molecules by anti-tumor necrosis factor alpha monoclonal antibody treatment in patients with rheumatoid arthritis.
OBJECTIVE The effect of chimeric anti-tumor necrosis factor alpha (TNF alpha) monoclonal antibody (MAb) therapy on synovial… 
Highly Cited
1993
Highly Cited
1993
Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha.
OBJECTIVE To evaluate the safety and efficacy of a chimeric monoclonal antibody to tumor necrosis factor alpha (TNF alpha) in the… 
Highly Cited
1990
Highly Cited
1990
Interleukin-4 (IL-4) inhibits secretion of IL-1 beta, tumor necrosis factor alpha, and IL-6 by human monocytes.
Monocytes activated by lipopolysaccharide (LPS) and interferon gamma (IFN gamma) rapidly secrete a number of monokines with… 
Highly Cited
1988
Highly Cited
1988
Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism
Manganous superoxide dismutase (MnSOD) scavenges potentially toxic superoxide radicals produced in the mitochondria. Tumor… 
Highly Cited
1987
Highly Cited
1987
Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha
The immunoregulatory effects of transforming growth factor beta (TGF- beta) and recombinant murine tumor necrosis factor alpha… 
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