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Tumor Necrosis Factor-alpha

Known as: Cachectin Tumor Necrosis Factor, Tumor Necrosis Factor-alpha [Chemical/Ingredient], Tumor Necrosis Factor alpha 
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines… 
National Institutes of Health

Related topics

Related topics

33 relations
A-Tumor Necrosis Fact SerPl-mCncCachexiaIn BloodNecrosis

Narrower (14)

F 4168F 4614LK-805PEG-modified tumor necrosis factor-alpha

Broader (2)

MonokinesTumor Necrosis Factors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2000
Highly Cited
2000
Distinct patterns of stimulus‐inducible chemokine mRNA accumulation in human fetal astrocytes and microglia
Interferon‐γ‐inducible 10 kd protein (IP‐10) is an ELR (Glu‐Leu‐Arg)− α chemokine with known chemotactic effects on T cells and… 
Highly Cited
1999
Highly Cited
1999
Soluble tumor necrosis factor receptors in chronic hepatitis C: a correlation with histological fibrosis and activity.
Highly Cited
1999
Highly Cited
1999
IV immunoglobulin reduces circulating proinflammatory cytokines in Guillain-Barré syndrome
Background: Treatment with human IV immunoglobulin (IVIg) modifies the course of Guillain-Barré syndrome (GBS), but its specific… 
Highly Cited
1997
Highly Cited
1997
A Leishmania protein that modulates interleukin (IL)‐12, IL‐10 and tumor necrosis factor‐α production and expression of B7‐1 in human monocyte‐derived antigen‐presenting cells
LeIF, a gene homologue of the eukaryotic initiation factor 4A was first described as a leishmanial antigen that induced a Th1… 
Highly Cited
1997
Highly Cited
1997
Genetic variation in the tumor necrosis factor alpha gene and the outcome of multiple sclerosis
The objective of this study was to determine whether sequence variation in the tumor necrosis factor alpha (TNFα) gene is… 
Highly Cited
1996
Highly Cited
1996
Interleukin-3 cooperates with tumor necrosis factor alpha for the development of human dendritic/Langerhans cells from cord blood CD34+ hematopoietic progenitor cells.
We have previously shown that tumor necrosis factor (TNF)alpha strongly potentiates the granulocyte-macrophage colony-stimulating… 
Highly Cited
1996
Highly Cited
1996
Use of transient CD4 lymphocyte depletion to prolong transgene expression of E1-deleted adenoviral vectors.
E1-deleted adenoviral vectors are increasingly being utilized for in vivo gene transfer. The potential use of these vectors is… 
Highly Cited
1992
Highly Cited
1992
Evidence for endocytosis of E‐selectin in human endothelial cells
E‐selectin is an inducible adhesion molecule on endothelial cells. The internalization of this glycoprotein was investigated on… 
Highly Cited
1991
Highly Cited
1991
Tumor necrosis factor alpha and interferon gamma modulate the expression of the vitronectin receptor (integrin beta 3) in human endothelial cells.
In this paper we show that tumor necrosis factor alpha (TNF alpha) and interferon gamma (IFN gamma) alter the expression of… 
Highly Cited
1988
Highly Cited
1988
Transcriptional and posttranscriptional modulation of myeloid colony-stimulating factor expression by tumor necrosis factor and other agents
Granulocyte (G) and granulocyte-macrophage (GM) colony-stimulating factors (CSF) are necessary for proliferation and… 
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