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Death receptors: signaling and modulation.
Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique…
Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.
A cell surface mechanism exists for the regulation of cellular responsiveness to pro-apoptotic stimuli in tumor cells.
Safety and antitumor activity of recombinant soluble Apo2 ligand.
Apo2L may have potent anticancer activity without significant toxicity toward normal tissues, and cooperated synergistically with the chemotherapeutic drugs 5-fluorouracil or CPT-11, causing substantial tumor regression or complete tumor ablation.
Targeting death and decoy receptors of the tumour-necrosis factor superfamily
- A. Ashkenazi
- Biology, MedicineNature Reviews Cancer
- 1 June 2002
Cancer cells often develop resistance to chemotherapy or irradiation through mutations in the p53 tumour-suppressor gene, which prevent apoptosis induction in response to cellular damage, so agents that are designed to activate death receptors or block decoy receptors might be used to kill tumour cells that are resistant to conventional cancer therapies.
Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family*
- R. Pitti, S. Marsters, S. Ruppert, C. Donahue, A. Moore, A. Ashkenazi
- Biology, ChemistryThe Journal of Biological Chemistry
- 31 May 1996
Results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death.
Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer
Certain tumours may escape FasL-dependent immune-cytotoxic attack by expressing a decoy receptor that blocks FasL, which was amplified in about half of 35 primary lung and colon tumours studied and DcR3 messenger RNA was expressed in malignant tissue.
Apoptosis control by death and decoy receptors.
Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.
Apo2L/TRAIL and its death and decoy receptors
This review focuses on the apoptotic signalling pathways stimulated by Apo2L/TRAIL and summarise what is known about its physiological role.
Molecular Determinants of Kinase Pathway Activation by Apo2 Ligand/Tumor Necrosis Factor-related Apoptosis-inducing Ligand*
- E. Varfolomeev, H. Maecker, A. Ashkenazi
- Biology, ChemistryJournal of Biological Chemistry
- 9 December 2005
It is shown that Apo2L/TRAIL activates kinase pathways by promoting the association of a secondary signaling complex, subsequent to assembly of a primary, death-inducing signaling complex (DISC), which recruited several factors involved in kinase activation by TNF.