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Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice
TLDR
The hypothesis that TNF is a mediator of lethal toxicity of endotoxin is supported, showing that the early biochemical alterations in the liver known to be necessary for sensitization to LPS are also necessary for sensitivity to TNF. Expand
HIV‐1 Tat potentiates TNF‐induced NF‐kappa B activation and cytotoxicity by altering the cellular redox state.
TLDR
It is demonstrated that the C‐terminal region of HIV‐1 Tat is required to suppress Mn‐SOD expression and to induce pro‐oxidative conditions reflected by a drop in reduced glutathione (GSH) and the GSH:oxidized GSH (GSSG) ratio. Expand
Sesquiterpene Lactones Specifically Inhibit Activation of NF-κB by Preventing the Degradation of IκB-α and IκB-β*
TLDR
Inhibition of NF-κB by SLs resulted in an enhanced cell killing of murine fibroblast cells by tumor necrosis factor-α and the analysis of the cellular redox state by fluorescence-activated cell sorter showed that the SLs had no direct or indirect anti-oxidant properties. Expand
Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta.
TLDR
Inhibition of NF-kappa B by SLs resulted in an enhanced cell killing of murine fibroblast cells by tumor necrosis factor-alpha and analysis of the cellular redox state by fluorescence-activated cell sorter showed that the SLs had no direct or indirect anti-oxidant properties. Expand
Adenosine and homocysteine together enhance TNF-mediated cytotoxicity but do not alter activation of nuclear factor-kappa B in L929 cells.
This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha-mediated cytotoxicity, but does not modulate activation of NF-kappa B transcription factor controlling theExpand
Peptides and hydrolysates from casein and soy protein modulate the release of vasoactive substances from human aortic endothelial cells.
TLDR
It is demonstrated that peptides and hydrolysate fractions from casein and soy protein influence endothelial cell function as evidenced by the modulation of endothelialcell proliferation and alterations in the release of vasoactive substances. Expand
Lipopolysaccharides of Gram-Negative Bacteria
TLDR
The studies indicate that at least some lipid A activities are not restricted to one specific structure, but are rather connected with general physicochemical properties. Expand
Structural investigations on the 2-keto-3-deoxyoctonate region of lipopolysaccharides.
TLDR
Results were obtained which indicate that the bridge between the polysaccharide portion of lipopolysaccharides and lipid A is formed by a branched KDO trisaccharide whose KDO side chain is randomly substituted by phosphorylethanolamine according to the formula. Expand
Isolation of mutants conditionally blocked in the biosynthesis of the 3-deoxy-D-manno-octulosonic-acid--lipid-A part of lipopolysaccharides derived from Salmonella typhimurium.
TLDR
Three mutants proved to be conditionally defective in dOclA metabolism, whereas one seems to be blocked at a relatively early step in lipid A synthesis, and studies of these mutants may shed light on the essential role of the complete dOClA--lipid A part of lipopolysaccharides in membrane function. Expand
Sphingosine-1-phosphate mobilizes intracellular calcium and activates transcription factor NF-kappa B in U937 cells.
TLDR
It is shown that SPP mobilizes intracellular calcium in U937 cells and for the first time the ability of SPP to activate the transcription factor NF-kappa B in these cells is demonstrated. Expand
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