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A network-based analysis of systemic inflammation in humans
Oligonucleotide and complementary DNA microarrays are being used to subclassify histologically similar tumours, monitor disease progress, and individualize treatment regimens. However, extracting newExpand
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A genomic storm in critically injured humans
Critical injury in humans induces a genomic storm with simultaneous changes in expression of innate and adaptive immunity genes.
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Genomic responses in mouse models poorly mimic human inflammatory diseases
A cornerstone of modern biomedical research is the use of mouse models to explore basic pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-go decisions to carry newExpand
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MyD88-dependent expansion of an immature GR-1+CD11b+ population induces T cell suppression and Th2 polarization in sepsis
Polymicrobial sepsis alters the adaptive immune response and induces T cell suppression and Th2 immune polarization. We identify a GR-1+CD11b+ population whose numbers dramatically increase andExpand
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Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice.
IL-1alpha and IL-1beta are potent inflammatory cytokines that contribute to a number of normal physiologic processes and to the development of a number of inflammatory diseases. Two IL-1R, the type IExpand
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ABSTRACT— An intact innate and acquired immune response are essential for defeating systemic microbial infections. Recognition molecules, inflammatory cells, and the cytokines they produce are theExpand
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Persistent inflammation and immunosuppression: A common syndrome and new horizon for surgical intensive care
ABSTRACT Surgical intensive care unit (ICU) stay of longer than 10 days is often described by the experienced intensivist as a “complicated clinical course” and is frequently attributed to persistentExpand
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Apoptosis in sepsis: a new target for therapeutic exploration.
The treatment of sepsis and septic shock remains a clinical conundrum, and recent prospective trials with biological response modifiers aimed at the inflammatory response have shown only modestExpand
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Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.
Tumor necrosis factor alpha (TNF alpha), a primary mediator of systemic responses to sepsis and infection, can be injurious to the organism when present in excessive quantities. Here we report thatExpand
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Cytokine signaling--regulation of the immune response in normal and critically ill states.
Cytokines are produced during the activation of innate and acquired immunity, and are the principal means for intercellular communication of a microbial invasion. Cytokines serve to initiate theExpand
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