Thymic T-Cell Selection

Known as: thymic T cell selection, thymic T-lymphocyte selection, Thymocyte Selection 
Bone marrow-derived stem cells in the thymus become educated to recognize complexes of self-major histocompatibility complex (MHC) molecules plus… (More)
National Institutes of Health

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Highly Cited
2002
Highly Cited
2002
CCR9 mediates chemotaxis in response to CCL25/thymus-expressed chemokine and is selectively expressed on T cells in the thymus… (More)
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Highly Cited
2002
Highly Cited
2002
In the thymus, pre-T cell receptor (pre-TCR)–mediated signaling and then TCR-mediated signaling initiate changes in gene… (More)
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Highly Cited
1998
Highly Cited
1998
Evolutionary mechanisms of origins of new gene function have been a subject of long-standing debate. Here we report a convincing… (More)
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Highly Cited
1998
Highly Cited
1998
During T cell development, thymocytes which are tolerant to self-peptides but reactive to foreign peptides are selected. The… (More)
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Highly Cited
1998
Highly Cited
1998
FADD is a cytoplasmic adapter molecule that links the family of death receptors to the activation of caspases during apoptosis… (More)
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Highly Cited
1997
Highly Cited
1997
T cell maturation requires the rearrangement of clonotypic T cell receptors (TCR) capable of interacting with major… (More)
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Highly Cited
1995
Highly Cited
1995
CD5 is a transmembrane protein that is expressed on the surface of T cells and a subset of B cells. The absence of CD5 rendered… (More)
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Highly Cited
1994
Highly Cited
1994
T lymphocyte maturation is dependent on interactions between the T cell receptor (TCR) expressed on the developing thymocyte and… (More)
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Highly Cited
1994
Highly Cited
1994
The mouse thymus was assessed for its ability to produce steroids. Cultured thymic non-T cells produced soluble pregnenolone and… (More)
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Highly Cited
1993
Highly Cited
1993
Thymocyte commitment to the CD4 helper versus CD8 cytotoxic lineage has not been satisfactorily established. Two models have been… (More)
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