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Thymic T-Cell Selection

Known as: thymic T cell selection, thymic T-lymphocyte selection, Thymocyte Selection 
Bone marrow-derived stem cells in the thymus become educated to recognize complexes of self-major histocompatibility complex (MHC) molecules plus… 
National Institutes of Health

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17 relations
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Broader (1)

T-Cell Differentiation in the Thymus

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells
Thymic epithelial cell differentiation, growth and function depend on the expression of the transcription factor Foxn1; however… 
Highly Cited
2013
Highly Cited
2013
Selection bias at the heterosexual HIV-1 transmission bottleneck
Introduction Heterosexual HIV-1 transmission is an inefficient process with rates reported at <1% per unprotected sexual exposure… 
Highly Cited
2007
Highly Cited
2007
Short‐term efficacy of pharmacotherapeutic interventions in osteoarthritic knee pain: A meta‐analysis of randomised placebo‐controlled trials
Highly Cited
1998
Highly Cited
1998
A role for FADD in T cell activation and development.
Highly Cited
1998
Highly Cited
1998
Preselection Thymocytes Are More Sensitive to T Cell Receptor Stimulation Than Mature T Cells
During T cell development, thymocytes which are tolerant to self-peptides but reactive to foreign peptides are selected. The… 
Highly Cited
1997
Highly Cited
1997
The Efficiency of CD4 Recruitment to Ligand-engaged TCR Controls the Agonist/Partial Agonist Properties of Peptide–MHC Molecule Ligands
One hypothesis seeking to explain the signaling and biological properties of T cell receptor for antigen (TCR) partial agonists… 
Highly Cited
1995
Highly Cited
1995
A role for CD5 in TCR-mediated signal transduction and thymocyte selection.
CD5 is a transmembrane protein that is expressed on the surface of T cells and a subset of B cells. The absence of CD5 rendered… 
Highly Cited
1994
Highly Cited
1994
Positive and negative thymocyte selection induced by different concentrations of a single peptide.
T lymphocyte maturation is dependent on interactions between the T cell receptor (TCR) expressed on the developing thymocyte and… 
Highly Cited
1994
Highly Cited
1994
Steroid production in the thymus: implications for thymocyte selection
The mouse thymus was assessed for its ability to produce steroids. Cultured thymic non-T cells produced soluble pregnenolone and… 
Highly Cited
1993
Highly Cited
1993
Another view of the selective model of thymocyte selection
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