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Inducible gene targeting in mice
A method of gene targeting that allows the inducible inactivation of a target gene in mice is presented. The method uses an interferon-responsive promoter to control the expression of CreExpand
Interleukin-10-deficient mice develop chronic enterocolitis
The results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract. Expand
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing.
The data suggest that Dicer participates in multiple, fundamental biological processes in a mammalian organism, ranging from stem cell differentiation to the maintenance of centromeric heterochromatin structure and Centromeric silencing. Expand
Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning
It is shown here that N-CAM-deficient mice generated by gene targeting appear healthy and fertile, but adult mutants show a 10% reduction in overall brain weight and a 36% decline in size of the olfactory bulb. Expand
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes
The genomic region encoding the miR-17-92 microRNA (miRNA) cluster is often amplified in lymphoma and other cancers, and cancer cells carrying this amplification have higher expression of miRNA in this cluster, and this mechanism probably contributed to the lymphoproliferative disease and autoimmunity ofmiR- 17-92-transgenic mice and contributes to lymphoma development in patients with amplifications of this coding region. Expand
Regulation of the Germinal Center Response by MicroRNA-155
It is shown that the evolutionarily conserved microRNA-155 has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell–dependent antibody response. Expand
B lymphocyte-specific, Cre-mediated mutagenesis in mice.
To selectively modify genes in B lymphocytes, mice are generated (designated CD19-Cre) which express cre under the transcriptional control of the B lineage-restricted CD19 gene. Expand
Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated
It is reported here that human IgM+IgD+ peripheral blood (PB) B cells expressing the CD27 cell surface antigen carry mutated V genes, in contrast to CD27-negative IgM-only tonsillar germinal center and plasma cells, which may represent a general marker for memory B cells in humans. Expand
Clonal selection and learning in the antibody system
A second selection process occurs during immune responses in which a new antibody repertoire is generated through somatic hypermutation, where only mutants binding antigen with high affinity survive to become memory cells. Expand